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Target
Xaa-Pro aminopeptidase 2
Ligand
BDBM197052
Substrate
n/a
Meas. Tech.
Enzyme Assay
pH
7.4±n/a
IC50
26±n/a nM
Comments
extracted
Citation
 Simmons, WH 4-Fluoro-Thio-containing inhibitors of APP2, compositions thereof and method of use US Patent  US9212206 Publication Date 12/15/2015 
Target
Name:
Xaa-Pro aminopeptidase 2
Synonyms:
Membrane-bound aminopeptidase P (APP2) | XPNPEP2 | XPP2_HUMAN | Xaa-Pro aminopeptidase 2
Type:
Enzyme
Mol. Mass.:
75618.88
Organism:
Homo sapiens (Human)
Description:
O43895
Residue:
674
Sequence:
MARAHWGCCPWLVLLCACAWGHTKPVDLGGQDVRNCSTNPPYLPVTVVNTTMSLTALRQQMQTQNLSAYIIPGTDAHMNEYIGQHDERRAWITGFTGSAGTAVVTMKKAAVWTDSRYWTQAERQMDCNWELHKEVGTTPIVTWLLTEIPAGGRVGFDPFLLSIDTWESYDLALQGSNRQLVSITTNLVDLVWGSERPPVPNQPIYALQEAFTGSTWQEKVSGVRSQMQKHQKVPTAVLLSALEETAWLFNLRASDIPYNPFFYSYTLLTDSSIRLFANKSRFSSETLSYLNSSCTGPMCVQIEDYSQVRDSIQAYSLGDVRIWIGTSYTMYGIYEMIPKEKLVTDTYSPVMMTKAVKNSKEQALLKASHVRDAVAVIRYLVWLEKNVPKGTVDEFSGAEIVDKFRGEEQFSSGPSFETISASGLNAALAHYSPTKELNRKLSSDEMYLLDSGGQYWDGTTDITRTVHWGTPSAFQKEAYTRVLIGNIDLSRLIFPAATSGRMVEAFARRALWDAGLNYGHGTGHGIGNFLCVHEWPVGFQSNNIAMAKGMFTSIEPGYYKDGEFGIRLEDVALVVEAKTKYPGSYLTFEVVSFVPYDRNLIDVSLLSPEHLQYLNRYYQTIREKVGPELQRRQLLEEFEWLQQHTEPLAARAPDTASWASVLVVSTLAILGWSV
  
Inhibitor
Name:
BDBM197052
Synonyms:
US9212206, V
Type:
Small organic molecule
Emp. Form.:
C21H33N3O5S
Mol. Mass.:
439.569
SMILES:
CC(C)C[C@H](S)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CC[C@@H](C1)C(O)=O |r|
Structure:
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