Reaction Details Report a problem with these data
Target
Histamine H3 receptor
Ligand
BDBM197114
Substrate
n/a
Meas. Tech.
LANCE Ultra cAMP Assay
Ki
0.1±n/a nM
Citation
 Wang, T; Zhang, X Carbamate/urea derivatives containing piperidin and piperazin rings as H3 receptor inhibitors US Patent  US9216182 Publication Date 12/22/2015 
Target
Name:
Histamine H3 receptor
Synonyms:
G-protein coupled receptor 97 | GPCR97 | HH3R | HISTAMINE H3 | HRH3 | HRH3_HUMAN | Histamine H3 receptor (H3) | Histamine H3L | Histamine receptor (H3 and H4)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
48691.47
Organism:
Homo sapiens (Human)
Description:
Binding assays were using CHO cells stably expressing hH3R receptors.
Residue:
445
Sequence:
MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTSSAFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAAGPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAVGAEAGEATLGGGGGGGSVASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSLAVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFRRAFTKLLCPQKLKIQPHSSLEHCWK
  
Inhibitor
Name:
BDBM197114
Synonyms:
US9216182, 1.60
Type:
Small organic molecule
Emp. Form.:
C21H30N4O4
Mol. Mass.:
402.4873
SMILES:
COC(=O)c1ccc(cn1)N1CCC(CC1)OC(=O)N1CCN(CC1)C1CCC1
Structure:
Search PDB for entries with ligand similarity: