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Target
D(2) dopamine receptor
Ligand
BDBM199158
Substrate
n/a
Meas. Tech.
Competitive Binding Assays
Ki
34.40±0.0 nM
Citation
 Li, W; Zhang, L; Xu, L; Yuan, C; Du, P; Chen, J; Zhen, X; Fu, W Functional reversal of (-)-Stepholidine analogues by replacement of benzazepine substructure using the ring-expansion strategy. Chem Biol Drug Des 88:599-607 (2016) [PubMed]  Article 
Target
Name:
D(2) dopamine receptor
Synonyms:
D(2) dopamine receptor | DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DRD2 | DRD2_HUMAN | Dopamine D2 receptor | Dopamine D2 receptor (D2) | Dopamine D2 receptor (D2R) | Dopamine D2A | Dopamine2-like | d2
Type:
Cell-surface receptors
Mol. Mass.:
50647.10
Organism:
Homo sapiens (Human)
Description:
P14416
Residue:
443
Sequence:
MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC
  
Inhibitor
Name:
BDBM199158
Synonyms:
3,11-dimethoxy-5,6,8,9,14,14a-hexahydrobenzo[4,5]azepino[2,1-a]isoquinoline-2,10-diol ((+)-15e) | 3,11-dimethoxy-5,6,8,9,14,14a-hexahydrobenzo[4,5]azepino[2,1-a]isoquinoline-2,10-diol ((-)-15e) | 3,11-dimethoxy-5,6,8,9,14,14a-hexahydrobenzo[4,5]azepino[2,1-a]isoquinoline-2,10-diol (15e)
Type:
Small organic molecule
Emp. Form.:
C20H23NO4
Mol. Mass.:
341.4009
SMILES:
COc1cc2CCN3CCc4c(CC3c2cc1O)ccc(OC)c4O
Structure:
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