Reaction Details Report a problem with these data
Target
D(1A) dopamine receptor
Ligand
BDBM199157
Substrate
n/a
Meas. Tech.
D1R Functional Assay
pH
7.5±n/a
IC50
3.345e+4±n/a nM
Comments
extracted
Citation
 Li, W; Zhang, L; Xu, L; Yuan, C; Du, P; Chen, J; Zhen, X; Fu, W Functional reversal of (-)-Stepholidine analogues by replacement of benzazepine substructure using the ring-expansion strategy. Chem Biol Drug Des 88:599-607 (2016) [PubMed]  Article 
Target
Name:
D(1A) dopamine receptor
Synonyms:
DA D1 receptor | DOPAMINE D1 | DRD1 | DRD1_HUMAN | Dopamine D1 receptor | Dopamine D1 receptor (D1R) | Dopamine D1A
Type:
Enzyme
Mol. Mass.:
49303.43
Organism:
Homo sapiens (Human)
Description:
P21728
Residue:
446
Sequence:
MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLAETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKNCQTTTGNGKPVECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGSGETQPFCIDSNTFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPATNNAIETVSINNNGAAMFSSHHEPRGSISKECNLVYLIPHAVGSSEDLKKEEAAGIARPLEKLSPALSVILDYDTDVSLEKIQPITQNGQHPT
  
Inhibitor
Name:
BDBM199157
Synonyms:
3,10,11-trimethoxy-5,6,8,9,14,14a-hexahydrobenzo[4,5]azepino[2,1-a]isoquinolin-2-ol (15d)
Type:
Small organic molecule
Emp. Form.:
C21H25NO4
Mol. Mass.:
355.4275
SMILES:
COc1cc2CCN3CCc4c(CC3c2cc1O)ccc(OC)c4OC
Structure:
Search PDB for entries with ligand similarity: