Reaction Details
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Report a problem with these dataTarget
Complement factor D [24-253]
Ligand
BDBM203865
Substrate
n/a
Meas. Tech.
Complement FD Thioesterolysis Assay
pH
7.5±n/a
Temperature
298.15±n/a K
IC50
1.37e+4± 8.7e+3 nM
Comments
extracted
Citation
Maibaum, J; Liao, SM; Vulpetti, A; Ostermann, N; Randl, S; Rüdisser, S; Lorthiois, E; Erbel, P; Kinzel, B; Kolb, FA; Barbieri, S; Wagner, J; Durand, C; Fettis, K; Dussauge, S; Hughes, N; Delgado, O; Hommel, U; Gould, T; Mac Sweeney, A; Gerhartz, B; Cumin, F; Flohr, S; Schubart, A; Jaffee, B; Harrison, R; Risitano, AM; Eder, J; Anderson, K Small-molecule factor D inhibitors targeting the alternative complement pathway. Nat Chem Biol 12:1105-1110 (2016) [PubMed] Article More Info.:
Target
Name:
Complement factor D [24-253]
Synonyms:
CFAD_HUMAN | CFD | Complement factor D (FD) catalytic domain (Human fD) | DF | PFD
Type:
Protein
Mol. Mass.:
24622.79
Organism:
Homo sapiens (Human)
Description:
P00746 (24-253 aa)
Residue:
230
Sequence:
GRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA
Inhibitor
Name:
BDBM203865
Synonyms:
Methyl (S)-2-((2-((3-(trifluoromethoxy)phenyl)carbamoyl)pyrrolidine-1-carboxamido)-methyl)benzoate (2)
Type:
Small organic molecule
Emp. Form.:
C22H22F3N3O5
Mol. Mass.:
465.4224
SMILES:
COC(=O)c1ccccc1CNC(=O)N1CCC[C@H]1C(=O)Nc1cccc(OC(F)(F)F)c1
Structure:
