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Target
Complement factor D [24-253]
Ligand
BDBM171272
Substrate
n/a
Meas. Tech.
Complement FD Thioesterolysis Assay
pH
7.5±n/a
Temperature
298.15±n/a K
IC50
17± 8 nM
Comments
extracted
Citation
 Maibaum, J; Liao, SM; Vulpetti, A; Ostermann, N; Randl, S; Rüdisser, S; Lorthiois, E; Erbel, P; Kinzel, B; Kolb, FA; Barbieri, S; Wagner, J; Durand, C; Fettis, K; Dussauge, S; Hughes, N; Delgado, O; Hommel, U; Gould, T; Mac Sweeney, A; Gerhartz, B; Cumin, F; Flohr, S; Schubart, A; Jaffee, B; Harrison, R; Risitano, AM; Eder, J; Anderson, K Small-molecule factor D inhibitors targeting the alternative complement pathway. Nat Chem Biol 12:1105-1110 (2016) [PubMed]  Article 
Target
Name:
Complement factor D [24-253]
Synonyms:
CFAD_HUMAN | CFD | Complement factor D (FD) catalytic domain (Human fD) | DF | PFD
Type:
Protein
Mol. Mass.:
24622.79
Organism:
Homo sapiens (Human)
Description:
P00746 (24-253 aa)
Residue:
230
Sequence:
GRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA
  
Inhibitor
Name:
BDBM171272
Synonyms:
1-(2-((1R,3S,5R)-3-(((R)-1-(3-Chloro-2-fluorophenyl)ethyl)carbamoyl)-2-azabicyclo[3.1.0]hexan-2-yl)-2-oxoethyl)-1H-pyrazolo[3,4-c]pyridine-3-carboxamide (6) | US9085555, 702
Type:
Small organic molecule
Emp. Form.:
C23H22ClFN6O3
Mol. Mass.:
484.911
SMILES:
C[C@@H](NC(=O)[C@@H]1C[C@H]2C[C@H]2N1C(=O)Cn1nc(C(N)=O)c2ccncc12)c1cccc(Cl)c1F |r|
Structure:
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