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Target
Isoform 2 of Protein mono-ADP-ribosyltransferase PARP3 (Long)
Ligand
BDBM207624
Substrate
n/a
Meas. Tech.
PARP-2 and PARP-3 Enzymatic Assay
IC50
185±n/a nM
Citation
 Zhou, C; Ren, B; Wang, H Fused tetra or penta-cyclic dihydrodiazepinocarbazolones as PARP inhibitors US Patent  US9260440 Publication Date 2/16/2016 
Target
Name:
Isoform 2 of Protein mono-ADP-ribosyltransferase PARP3 (Long)
Synonyms:
ADPRT3 | ADPRTL3 | PARP3 | PARP3_HUMAN | Poly [ADP-ribose] polymerase 3 (PARP-3) | Protein mono-ADP-ribosyltransferase PARP3 (Long)
Type:
Protein
Mol. Mass.:
60847.85
Organism:
Homo sapiens (Human)
Description:
Q9Y6F1-2
Residue:
540
Sequence:
MSLLFLAMAPKPKPWVQTEGPEKKKGRQAGREEDPFRSTAEALKAIPAEKRIIRVDPTCPLSSNPGTQVYEDYNCTLNQTNIENNNNKFYIIQLLQDSNRFFTCWNHWGRVGEVGQSKINHFTRLEDAKKDFEKKFREKTKNNWAERDHFVSHPGKYTLIEVQAEDEAQEAVVKVDRGPVRTVTKRVQPCSLDPATQKLITNIFSKEMFKNTMALMDLDVKKMPLGKLSKQQIARGFEALEALEEALKGPTDGGQSLEELSSHFYTVIPHNFGHSQPPPINSPELLQAKKDMLLVLADIELAQALQAVSEQEKTVEEVPHPLDRDYQLLKCQLQLLDSGAPEYKVIQTYLEQTGSNHRCPTLQHIWKVNQEGEEDRFQAHSKLGNRKLLWHGTNMAVVAAILTSGLRIMPHSGGRVGKGIYFASENSKSAGYVIGMKCGAHHVGYMFLGEVALGREHHINTDNPSLKSPPPGFDSVIARGHTEPDPTQDTELELDGQQVVVPQGQPVPCPEFSSSTFSQSEYLIYQESQCRLRYLLEVHL
  
Inhibitor
Name:
BDBM207624
Synonyms:
US10501467, Example 69 | US9260440, 69 | US9617273, Example 69
Type:
Small organic molecule
Emp. Form.:
C16H15FN4O
Mol. Mass.:
298.3149
SMILES:
C[C@]12CCCN1Cc1n[nH]c(=O)c3cc(F)cc4[nH]c2c1c34 |r|
Structure:
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