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Target
Isoform D of Beta-secretase 1 (BACE-I-432)
Ligand
BDBM50078349
Substrate
n/a
Meas. Tech.
BACE-1 Cell-Free Assay
pH
4.5±n/a
Temperature
310.15±n/a K
IC50
704±n/a nM
Comments
extracted
Citation
 Brodney, MA; Beck, EM; Butler, CR; Davoren, JE Alkyl-substituted hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds US Patent  US9260455 Publication Date 2/16/2016 
Target
Name:
Isoform D of Beta-secretase 1 (BACE-I-432)
Synonyms:
BACE | BACE1 | BACE1_HUMAN | Beta-secretase 1 (BACE-I-432) | Beta-secretase 1 (BACE1) | KIAA1149
Type:
Protein
Mol. Mass.:
48152.67
Organism:
Homo sapiens (Human)
Description:
P56817-4
Residue:
432
Sequence:
MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK
  
Inhibitor
Name:
BDBM50078349
Synonyms:
CHEMBL3414707 | US9260455, 3
Type:
Small organic molecule
Emp. Form.:
C14H16F2N2OS
Mol. Mass.:
298.351
SMILES:
[H][C@]12CSC(N)=N[C@]1(CO[C@@H](C)C2)c1ccc(F)cc1F |r,c:5|
Structure:
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