Reaction Details Report a problem with these data
Target
Histone deacetylase 1
Ligand
BDBM207804
Substrate
n/a
Meas. Tech.
HDAC enzyme inhibitionAssay
IC50
3564±n/a nM
Citation
 Rusche, JR; Peet, NP; Hopper, AT Compositions including 6-aminohexanoic acid derivatives as HDAC inhibitors US Patent  US9265734 Publication Date 2/23/2016 
Target
Name:
Histone deacetylase 1
Synonyms:
Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1
Type:
Enzyme
Mol. Mass.:
55090.27
Organism:
Homo sapiens (Human)
Description:
Q13547
Residue:
482
Sequence:
MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEFSDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVKLA
  
Inhibitor
Name:
BDBM207804
Synonyms:
US9265734, R85
Type:
Small organic molecule
Emp. Form.:
C20H22F3N3O2
Mol. Mass.:
393.4028
SMILES:
Nc1ccccc1NC(=O)CCCCCNC(=O)c1ccccc1C(F)(F)F
Structure:
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