Reaction Details Report a problem with these data
Target
GDH/6PGL endoplasmic bifunctional protein
Ligand
BDBM50446130
Substrate
n/a
Meas. Tech.
H6PD Activity Assay
IC50
1.8e+4±n/a nM
Citation
 Knezevic, CE; Wright, G; Remsing Rix, LL; Kim, W; Kuenzi, BM; Luo, Y; Watters, JM; Koomen, JM; Haura, EB; Monteiro, AN; Radu, C; Lawrence, HR; Rix, U Proteome-wide Profiling of Clinical PARP Inhibitors Reveals Compound-Specific Secondary Targets. Cell Chem Biol 23:1490-1503 (2016) [PubMed]  Article 
Target
Name:
GDH/6PGL endoplasmic bifunctional protein
Synonyms:
G6PE_HUMAN | GDH | H6PD | Hexose-6-phosphate dehydrogenase (H6PD)
Type:
Protein
Mol. Mass.:
88905.23
Organism:
Homo sapiens (Human)
Description:
O95479
Residue:
791
Sequence:
MWNMLIVAMCLALLGCLQAQELQGHVSIILLGATGDLAKKYLWQGLFQLYLDEAGRGHSFSFHGAALTAPKQGQELMAKALESLSCPKDMAPSHCAEHKDQFLQLSQYRQLKTAEDYQALNKDIEAQLQHAGLREAGRIFYFSVPPFAYEDIARNINSSCRPGPGAWLRVVLEKPFGHDHFSAQQLATELGTFFQEEEMYRVDHYLGKQAVAQILPFRDQNRKALDGLWNRHHVERVEIIMKETVDAEGRTSFYEEYGVIRDVLQNHLTEVLTLVAMELPHNVSSAEAVLRHKLQVFQALRGLQRGSAVVGQYQSYSEQVRRELQKPDSFHSLTPTFAAVLVHIDNLRWEGVPFILMSGKALDERVGYARILFKNQACCVQSEKHWAAAQSQCLPRQLVFHIGHGDLGSPAVLVSRNLFRPSLPSSWKEMEGPPGLRLFGSPLSDYYAYSPVRERDAHSVLLSHIFHGRKNFFITTENLLASWNFWTPLLESLAHKAPRLYPGGAENGRLLDFEFSSGRLFFSQQQPEQLVPGPGPAPMPSDFQVLRAKYRESPLVSAWSEELISKLANDIEATAVRAVRRFGQFHLALSGGSSPVALFQQLATAHYGFPWAHTHLWLVDERCVPLSDPESNFQGLQAHLLQHVRIPYYNIHPMPVHLQQRLCAEEDQGAQIYAREISALVANSSFDLVLLGMGADGHTASLFPQSPTGLDGEQLVVLTTSPSQPHRRMSLSLPLINRAKKVAVLVMGRMKREITTLVSRVGHEPKKWPISGVLPHSGQLVWYMDYDAFLG
  
Inhibitor
Name:
BDBM50446130
Synonyms:
AG-014699 | AG-14447 | RUCAPARIB CAMSYLATE | Rucaparib
Type:
Small organic molecule
Emp. Form.:
C19H18FN3O
Mol. Mass.:
323.3641
SMILES:
CNCc1ccc(cc1)-c1[nH]c2cc(F)cc3C(=O)NCCc1c23
Structure:
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