Reaction Details Report a problem with these data
Target
Dihydrofolate reductase type 1 from Tn4003
Ligand
BDBM210931
Substrate
n/a
Meas. Tech.
DHFR Inhibition Assay
IC50
9.8e+2± 8 nM
Citation
 Reeve, SM; Scocchera, EW; G-Dayanadan, N; Keshipeddy, S; Krucinska, J; Hajian, B; Ferreira, J; Nailor, M; Aeschlimann, J; Wright, DL; Anderson, AC MRSA Isolates from United States Hospitals Carry dfrG and dfrK Resistance Genes and Succumb to Propargyl-Linked Antifolates. Cell Chem Biol 23:1458-1467 (2016) [PubMed]  Article 
Target
Name:
Dihydrofolate reductase type 1 from Tn4003
Synonyms:
DYRA_STAAU | Dihydrofolate reductase (DfrA) | dfrA
Type:
Protein
Mol. Mass.:
18461.80
Organism:
Staphylococcus aureus
Description:
P13955
Residue:
161
Sequence:
MTLSIIVAHDKQRVIGYQNQLPWHLPNDLKHIKQLTTGNTLVMARKTFNSIGKPLPNRRNVVLTNQASFHHEGVDVINSLDEIKELSGHVFIFGGQTLYEAMIDQVDDMYITVIDGKFQGDTFFPPYTFENWEVESSVEGQLDEKNTIPHTFLHLVRRKGK
  
Inhibitor
Name:
BDBM210931
Synonyms:
UCP1175
Type:
Small organic molecule
Emp. Form.:
C23H22N4O3
Mol. Mass.:
402.4458
SMILES:
CCc1nc(N)nc(N)c1C#CCc1cc(OC)cc(c1)-c1ccc(cc1)C(O)=O
Structure:
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