Reaction Details Report a problem with these data
Target
Dihydrofolate reductase
Ligand
BDBM210934
Substrate
n/a
Meas. Tech.
DHFR Inhibition Assay
IC50
54± 5 nM
Citation
 Reeve, SM; Scocchera, EW; G-Dayanadan, N; Keshipeddy, S; Krucinska, J; Hajian, B; Ferreira, J; Nailor, M; Aeschlimann, J; Wright, DL; Anderson, AC MRSA Isolates from United States Hospitals Carry dfrG and dfrK Resistance Genes and Succumb to Propargyl-Linked Antifolates. Cell Chem Biol 23:1458-1467 (2016) [PubMed]  Article 
Target
Name:
Dihydrofolate reductase
Synonyms:
Dihydrofolate reductase (DfrK)
Type:
Protein
Mol. Mass.:
19251.04
Organism:
Staphylococcus aureus
Description:
C7C2U7
Residue:
163
Sequence:
MKVSLIAAMDKNRVIGKENDIPWRIPEDWEYVKNTTKGYPIILGRKNLESIGRALPGRRNIILTRDKGFSFNGCEIVHSIEDVFELCNSEEEIFIFGGEQIYNLFLPYVEKMYITKIHYEFEGDTFFPEVNYEEWNEVSVTQGITNEKNPYTYYFHIYERKAS
  
Inhibitor
Name:
BDBM210934
Synonyms:
UCP1206
Type:
Small organic molecule
Emp. Form.:
C24H22N4O4
Mol. Mass.:
430.4559
SMILES:
CCc1nc(N)nc(N)c1C#C[C@H](C)c1cc2OCOc2c(c1)-c1ccc(cc1)C(O)=O |r|
Structure:
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