Reaction Details Report a problem with these data
Target
ATP-dependent DNA helicase DinG
Ligand
BDBM213233
Substrate
OX-1-G2'
Meas. Tech.
Helicase Assays
pH
8±n/a
IC50
1.0±0.1 nM
Comments
extracted
Citation
 Bharti, SK; Sommers, JA; George, F; Kuper, J; Hamon, F; Shin-ya, K; Teulade-Fichou, MP; Kisker, C; Brosh, RM Specialization among iron-sulfur cluster helicases to resolve G-quadruplex DNA structures that threaten genomic stability. J Biol Chem 288:28217-29 (2013) [PubMed]  Article 
Target
Name:
ATP-dependent DNA helicase DinG
Synonyms:
DING_ECOLI | DNA-damage-inducible protein G (DinG) | dinG | rarB
Type:
Protein
Mol. Mass.:
81449.89
Organism:
Escherichia coli (Enterobacteria)
Description:
P27296
Residue:
716
Sequence:
MALTAALKAQIAAWYKALQEQIPDFIPRAPQRQMIADVAKTLAGEEGRHLAIEAPTGVGKTLSYLIPGIAIAREEQKTLVVSTANVALQDQIYSKDLPLLKKIIPDLKFTAAFGRGRYVCPRNLTALASTEPTQQDLLAFLDDELTPNNQEEQKRCAKLKGDLDTYKWDGLRDHTDIAIDDDLWRRLSTDKASCLNRNCYYYRECPFFVARREIQEAEVVVANHALVMAAMESEAVLPDPKNLLLVLDEGHHLPDVARDALEMSAEITAPWYRLQLDLFTKLVATCMEQFRPKTIPPLAIPERLNAHCEELYELIASLNNILNLYMPAGQEAEHRFAMGELPDEVLEICQRLAKLTEMLRGLAELFLNDLSEKTGSHDIVRLHRLILQMNRALGMFEAQSKLWRLASLAQSSGAPVTKWATREEREGQLHLWFHCVGIRVSDQLERLLWRSIPHIIVTSATLRSLNSFSRLQEMSGLKEKAGDRFVALDSPFNHCEQGKIVIPRMRVEPSIDNEEQHIAEMAAFFRKQVESKKHLGMLVLFASGRAMQRFLDYVTDLRLMLLVQGDQPRYRLVELHRKRVANGERSVLVGLQSFAEGLDLKGDLLSQVHIHKIAFPPIDSPVVITEGEWLKSLNRYPFEVQSLPSASFNLIQQVGRLIRSHGCWGEVVIYDKRLLTKNYGKRLLDALPVFPIEQPEVPEGIVKKKEKTKSPRRRRR
  
Inhibitor
Name:
BDBM213233
Synonyms:
Telomestatin (TMS)
Type:
Small organic molecule
Emp. Form.:
C26H14N8O7S
Mol. Mass.:
582.504
SMILES:
[H]C12CSC(=N1)c1coc(n1)-c1coc(n1)-c1coc(n1)-c1coc(n1)-c1coc(n1)-c1nc(oc1C)-c1nc2oc1C |c:4|
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
OX-1-G2'
Synonyms:
n/a
Type:
DNA
Mol. Mass.:
2700.87
Organism:
n/a
Description:
G4 DNA substrate
Residue:
32
Sequence:
ACTGTCCTACTTGATATTTTGGGGTTTTGGGG