Reaction Details Report a problem with these data
Target
ATP-dependent DNA helicase DinG
Ligand
BDBM50376748
Substrate
TP-G4
Meas. Tech.
Helicase Assays
pH
8±n/a
IC50
50±10 nM
Comments
extracted
Citation
 Bharti, SK; Sommers, JA; George, F; Kuper, J; Hamon, F; Shin-ya, K; Teulade-Fichou, MP; Kisker, C; Brosh, RM Specialization among iron-sulfur cluster helicases to resolve G-quadruplex DNA structures that threaten genomic stability. J Biol Chem 288:28217-29 (2013) [PubMed]  Article 
Target
Name:
ATP-dependent DNA helicase DinG
Synonyms:
DING_ECOLI | DNA-damage-inducible protein G (DinG) | dinG | rarB
Type:
Protein
Mol. Mass.:
81449.89
Organism:
Escherichia coli (Enterobacteria)
Description:
P27296
Residue:
716
Sequence:
MALTAALKAQIAAWYKALQEQIPDFIPRAPQRQMIADVAKTLAGEEGRHLAIEAPTGVGKTLSYLIPGIAIAREEQKTLVVSTANVALQDQIYSKDLPLLKKIIPDLKFTAAFGRGRYVCPRNLTALASTEPTQQDLLAFLDDELTPNNQEEQKRCAKLKGDLDTYKWDGLRDHTDIAIDDDLWRRLSTDKASCLNRNCYYYRECPFFVARREIQEAEVVVANHALVMAAMESEAVLPDPKNLLLVLDEGHHLPDVARDALEMSAEITAPWYRLQLDLFTKLVATCMEQFRPKTIPPLAIPERLNAHCEELYELIASLNNILNLYMPAGQEAEHRFAMGELPDEVLEICQRLAKLTEMLRGLAELFLNDLSEKTGSHDIVRLHRLILQMNRALGMFEAQSKLWRLASLAQSSGAPVTKWATREEREGQLHLWFHCVGIRVSDQLERLLWRSIPHIIVTSATLRSLNSFSRLQEMSGLKEKAGDRFVALDSPFNHCEQGKIVIPRMRVEPSIDNEEQHIAEMAAFFRKQVESKKHLGMLVLFASGRAMQRFLDYVTDLRLMLLVQGDQPRYRLVELHRKRVANGERSVLVGLQSFAEGLDLKGDLLSQVHIHKIAFPPIDSPVVITEGEWLKSLNRYPFEVQSLPSASFNLIQQVGRLIRSHGCWGEVVIYDKRLLTKNYGKRLLDALPVFPIEQPEVPEGIVKKKEKTKSPRRRRR
  
Inhibitor
Name:
BDBM50376748
Synonyms:
CHEMBL259739 | Phen-DC3
Type:
Small organic molecule
Emp. Form.:
C34H26N6O2
Mol. Mass.:
550.6081
SMILES:
C[n+]1cc(NC(=O)c2ccc3ccc4ccc(nc4c3n2)C(=O)Nc2c[n+](C)c3ccccc3c2)cc2ccccc12
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
TP-G4
Synonyms:
n/a
Type:
DNA
Mol. Mass.:
3656.91
Organism:
n/a
Description:
G4 DNA substrate
Residue:
49
Sequence:
TGGACCAGACCTAGCAGCTATGGGGGAGCTGGGGAAGGTGGGAATGTGA