Reaction Details Report a problem with these data
Target
Serine/threonine-protein kinase PAK 1 [249-545,K299R]
Ligand
BDBM213235
Substrate
n/a
Meas. Tech.
Z'-LYTEBiochemical Assay
IC50
20±n/a nM
Citation
Licciulli, S; Maksimoska, J; Zhou, C; Troutman, S; Kota, S; Liu, Q; Duron, S; Campbell, D; Chernoff, J; Field, J; Marmorstein, R; Kissil, JL FRAX597, a small molecule inhibitor of the p21-activated kinases, inhibits tumorigenesis of neurofibromatosis type 2 (NF2)-associated Schwannomas. J Biol Chem 288:29105-14 (2013) [PubMed] Article
More Info.:
Target
Name:
Serine/threonine-protein kinase PAK 1 [249-545,K299R]
Synonyms:
PAK1 | PAK1_HUMAN | p21-Activated kinase 1 (PAK1)
Type:
Enzyme
Mol. Mass.:
33244.90
Organism:
Homo sapiens (Human)
Description:
Human PAK1 truncation (249-545 aa) with K299R mutation
Residue:
297
Sequence:
SDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIRQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPEKLSAIFRDFLNRCLEMDVEKRGSAKELLQHQFLKIAKPLSSLTPLIAAAKEATKNNH