Reaction Details Report a problem with these data
Target
Dual specificity protein kinase TTK [2-857]
Ligand
BDBM213743
Substrate
n/a
Meas. Tech.
MPS1 Kinase Activity Assay
pH
7.5±n/a
IC50
<2e+2±n/a nM
Comments
extracted
Citation
 Casuscelli, F; Brasca, MG; Caldarelli, M; Cervi, G; Disingrini, T; Quartieri, F Pyrazolyl-pyrimidine derivatives as kinase inhibitors US Patent  US9284298 Publication Date 3/15/2016 
Target
Name:
Dual specificity protein kinase TTK [2-857]
Synonyms:
Dual specificity protein kinase TTK (MPS1) | MPS1 | MPS1L1 | TTK | TTK_HUMAN
Type:
Enzyme
Mol. Mass.:
96955.60
Organism:
Homo sapiens (Human)
Description:
residues 2-857 of the full length sequence P33981
Residue:
856
Sequence:
ESEDLSGRELTIDSIMNKVRDIKNKFKNEDLTDELSLNKISADTTDNSGTVNQIMMMANNPEDWLSLLLKLEKNSVPLSDALLNKLIGRYSQAIEALPPDKYGQNESFARIQVRFAELKAIQEPDDARDYFQMARANCKKFAFVHISFAQFELSQGNVKKSKQLLQKAVERGAVPLEMLEIALRNLNLQKKQLLSEEEKKNLSASTVLTAQESFSGSLGHLQNRNNSCDSRGQTTKARFLYGENMPPQDAEIGYRNSLRQTNKTKQSCPFGRVPVNLLNSPDCDVKTDDSVVPCFMKRQTSRSECRDLVVPGSKPSGNDSCELRNLKSVQNSHFKEPLVSDEKSSELIITDSITLKNKTESSLLAKLEETKEYQEPEVPESNQKQWQSKRKSECINQNPAASSNHWQIPELARKVNTEQKHTTFEQPVFSVSKQSPPISTSKWFDPKSICKTPSSNTLDDYMSCFRTPVVKNDFPPACQLSTPYGQPACFQQQQHQILATPLQNLQVLASSSANECISVKGRIYSILKQIGSGGSSKVFQVLNEKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSDKIIRLYDYEITDQYIYMVMECGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLIVDGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQQIINQISKLHAIIDPNHEIEFPDIPEKDLQDVLKCCLKRDPKQRISIPELLAHPYVQIQTHPVNQMAKGTTEEMKYVLGQLVGLNSPNSILKAAKTLYEHYSGGESHNSSSSKTFEKKRGKK
  
Inhibitor
Name:
BDBM213743
Synonyms:
US9284298, 8
Type:
Small organic molecule
Emp. Form.:
C32H40N8O3
Mol. Mass.:
584.7118
SMILES:
CCc1cccc(CC)c1NC(=O)c1cc(-c2ccnc(Nc3ccc(cc3OC)N3CCN(CCO)CC3)n2)n(C)n1
Structure:
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