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Target
Arginase-2, mitochondrial
Ligand
BDBM290420
Substrate
n/a
Meas. Tech.
Inhibition Assay of Arginase
pH
7.4±n/a
Temperature
298.15±n/a K
IC50
<250±n/a nM
Comments
extracted
Citation
 Van Zandt, M; Jagdmann, GE Arginase inhibitors as therapeutics US Patent  US10098902 Publication Date 10/16/2018 
Target
Name:
Arginase-2, mitochondrial
Synonyms:
ARG2 | ARGI2_HUMAN | Arginase II | Kidney-type arginase | Non-hepatic arginase | Type II arginase
Type:
PROTEIN
Mol. Mass.:
38576.93
Organism:
Homo sapiens (Human)
Description:
ChEMBL_978892
Residue:
354
Sequence:
MSLRGSLSRLLQTRVHSILKKSVHSVAVIGAPFSQGQKRKGVEHGPAAIREAGLMKRLSSLGCHLKDFGDLSFTPVPKDDLYNNLIVNPRSVGLANQELAEVVSRAVSDGYSCVTLGGDHSLAIGTISGHARHCPDLCVVWVDAHADINTPLTTSSGNLHGQPVSFLLRELQDKVPQLPGFSWIKPCISSASIVYIGLRDVDPPEHFILKNYDIQYFSMRDIDRLGIQKVMERTFDLLIGKRQRPIHLSFDIDAFDPTLAPATGTPVVGGLTYREGMYIAEEIHNTGLLSALDLVEVNPQLATSEEEAKTTANLAVDVIASSFGQTREGGHIVYDQLPTPSSPDESENQARVRI
  
Inhibitor
Name:
BDBM290420
Synonyms:
(3R,4S)-3-amino-4-(3-boronopropyl)-1-(7-chloro-1,2,3,4- tetrahydroisoquinoline-3-carbonyl)pyrrolidine-3-carboxylic acid | US10098902, Example 56 | US11389464, Example 56
Type:
Small organic molecule
Emp. Form.:
C18H25BClN3O5
Mol. Mass.:
409.672
SMILES:
N[C@]1(CN(C[C@@H]1CCCB(O)O)C(=O)C1Cc2ccc(Cl)cc2CN1)C(O)=O |r|
Structure:
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