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Target
Oligo-1,6-glucosidase IMA1
Ligand
BDBM222218
Substrate
n/a
Meas. Tech.
α-Glucosidase Inhibition Assay
IC50
1.747e+4± 3 nM
Citation
 Chaudhry, F; Naureen, S; Huma, R; Shaukat, A; Al-Rashida, M; Asif, N; Ashraf, M; Munawar, MA; Khan, MA In search of new a-glucosidase inhibitors: Imidazolylpyrazole derivatives. Bioorg Chem 71:102-109 (2017) [PubMed]  Article 
Target
Name:
Oligo-1,6-glucosidase IMA1
Synonyms:
α-glucosidase | Alpha-glucosidase | Alpha-glucosidase (α-glucosidase) | IMA1 | MALX3_YEAST | Oligo-1,6-glucosidase
Type:
Protein
Mol. Mass.:
68577.59
Organism:
Saccharomyces cerevisiae S288c (Baker's yeast)
Description:
n/a
Residue:
589
Sequence:
MTISSAHPETEPKWWKEATFYQIYPASFKDSNDDGWGDMKGIASKLEYIKELGADAIWISPFYDSPQDDMGYDIANYEKVWPTYGTNEDCFALIEKTHKLGMKFITDLVINHCSSEHEWFKESRSSKTNPKRDWFFWRPPKGYDAEGKPIPPNNWKSYFGGSAWTFDEKTQEFYLRLFCSTQPDLNWENEDCRKAIYESAVGYWLDHGVDGFRIDVGSLYSKVVGLPDAPVVDKNSTWQSSDPYTLNGPRIHEFHQEMNQFIRNRVKDGREIMTVGEMQHASDETKRLYTSASRHELSELFNFSHTDVGTSPLFRYNLVPFELKDWKIALAELFRYINGTDCWSTIYLENHDQPRSITRFGDDSPKNRVISGKLLSVLLSALTGTLYVYQGQELGQINFKNWPVEKYEDVEIRNNYNAIKEEHGENSEEMKKFLEAIALISRDHARTPMQWSREEPNAGFSGPSAKPWFYLNDSFREGINVEDEIKDPNSVLNFWKEALKFRKAHKDITVYGYDFEFIDLDNKKLFSFTKKYNNKTLFAALNFSSDATDFKIPNDDSSFKLEFGNYPKKEVDASSRTLKPWEGRIYISE
  
Inhibitor
Name:
BDBM222218
Synonyms:
3-([1,1'-Biphenyl]-4-yl)-4-(4,5-diphenyl-1H-imidazol-2-yl)-1-phenyl-1H-pyrazole (2g)
Type:
Small organic molecule
Emp. Form.:
C36H26N4
Mol. Mass.:
514.6184
SMILES:
c1c(-c2nc(c([nH]2)-c2ccccc2)-c2ccccc2)c(nn1-c1ccccc1)-c1ccc(cc1)-c1ccccc1
Structure:
Search PDB for entries with ligand similarity: