Reaction Details Report a problem with these data
Target
Histone deacetylase 2
Ligand
BDBM222224
Substrate
n/a
Meas. Tech.
HDAC2 Enzyme Assay
IC50
1.36e+3± 8e+1 nM
Citation
 Huong, TT; Dung, DT; Huan, NV; Cuong, LV; Hai, PT; Huong, LT; Kim, J; Kim, YG; Han, SB; Nam, NH Novel N-hydroxybenzamides incorporating 2-oxoindoline with unexpected potent histone deacetylase inhibitory effects and antitumor cytotoxicity. Bioorg Chem 71:160-169 (2017) [PubMed]  Article 
Target
Name:
Histone deacetylase 2
Synonyms:
Cereblon/Histone deacetylase 2 | HD2 | HDAC2 | HDAC2_HUMAN | Histone deacetylase 2 (HDAC2) | Human HDAC2
Type:
Chromatin regulator; hydrolase; repressor
Mol. Mass.:
55356.54
Organism:
Homo sapiens (Human)
Description:
Q92769
Residue:
488
Sequence:
MAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAGAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQIFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLGGGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYMEKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEEFSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDTKGTKSEQLSNP
  
Inhibitor
Name:
BDBM222224
Synonyms:
4-((4-((5-Fluoro-3-(hydroxyimino)-2-oxoindolin-1-yl)methyl)-1H-1,2,3-triazol-1-yl)methyl)-N-hydroxybenzamide (4b)
Type:
Small organic molecule
Emp. Form.:
C19H15FN6O4
Mol. Mass.:
410.3586
SMILES:
ONC(=O)c1ccc(Cn2cc(CN3C(=O)\C(=N/O)c4cc(F)ccc34)nn2)cc1
Structure:
Search PDB for entries with ligand similarity: