Reaction Details Report a problem with these data
Target
Histone deacetylase 2
Ligand
BDBM222235
Substrate
n/a
Meas. Tech.
HDAC2 Enzyme Assay
IC50
5.0e+2± 6e+1 nM
Citation
 Huong, TT; Dung, DT; Huan, NV; Cuong, LV; Hai, PT; Huong, LT; Kim, J; Kim, YG; Han, SB; Nam, NH Novel N-hydroxybenzamides incorporating 2-oxoindoline with unexpected potent histone deacetylase inhibitory effects and antitumor cytotoxicity. Bioorg Chem 71:160-169 (2017) [PubMed]  Article 
Target
Name:
Histone deacetylase 2
Synonyms:
Cereblon/Histone deacetylase 2 | HD2 | HDAC2 | HDAC2_HUMAN | Histone deacetylase 2 (HDAC2) | Human HDAC2
Type:
Chromatin regulator; hydrolase; repressor
Mol. Mass.:
55356.54
Organism:
Homo sapiens (Human)
Description:
Q92769
Residue:
488
Sequence:
MAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAGAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQIFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLGGGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYMEKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEEFSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDTKGTKSEQLSNP
  
Inhibitor
Name:
BDBM222235
Synonyms:
N-Hydroxy-4-((3-(hydroxyimino)-5-methoxy-2-oxoindolin-1-yl)methyl)benzamide (6f)
Type:
Small organic molecule
Emp. Form.:
C17H15N3O5
Mol. Mass.:
341.3181
SMILES:
COc1ccc2N(Cc3ccc(cc3)C(=O)NO)C(=O)\C(=N/O)c2c1
Structure:
Search PDB for entries with ligand similarity: