Target
Enoyl-[acyl-carrier-protein] reductase [NADH]
Ligand
BDBM97444
Substrate
n/a
Meas. Tech.
Inhibition Kinetics Assay
pH
8±0
Temperature
298.15±0 K
Ki
1±0 nM
Citation
 Neckles, CEltschkner, SCummings, JEHirschbeck, MDaryaee, FBommineni, GRZhang, ZSpagnuolo, LYu, WDavoodi, SSlayden, RAKisker, CTonge, PJ Rationalizing the Binding Kinetics for the Inhibition of the Burkholderia pseudomallei FabI1 Enoyl-ACP Reductase. Biochemistry 56:1865-1878 (2017) [PubMed]  Article 
Target
Name:
Enoyl-[acyl-carrier-protein] reductase [NADH]
Synonyms:
Enoyl-ACP reductase (FabI1)
Type:
Enzyme
Mol. Mass.:
27824.56
Organism:
Burkholderia pseudomallei
Description:
Q3JG55
Residue:
253
Sequence:
MRLQHKRGLIIGIANENSIAFGCARVMREQGAELALTYLNEKAEPYVRPLAQRLDSRLVVPCDVREPGRLEDVFARIAQEWGQLDFVLHSIAYAPKEDLHRRVTDCSQAGFAMAMDVSCHSFIRVARLAEPLMTNGGCLLTVTFYGAERAVEDYNLMGPVKAALEGSVRYLAAELGPRRIRVHALSPGPLKTRAASGIDRFDALLERVRERTPGHRLVDIDDVGHVAAFLASDDAAALTGNVEYIDGGYHVVG
  
Inhibitor
Name:
BDBM97444
Synonyms:
PT443
Type:
Small molecule
Emp. Form.:
C13H8BrNO2
Mol. Mass.:
290.112
SMILES:
Oc1cc(Br)ccc1Oc1ccccc1C#N
Structure:
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