Reaction Details Report a problem with these data
Target
Phosphoenolpyruvate carboxykinase, cytosolic [GTP] [H477R]
Ligand
BDBM223201
Substrate
n/a
Meas. Tech.
PEPCK Inhibition Assay
Ki
3.7e+4± 8e+3 nM
Citation
 Cui, DS; Broom, A; Mcleod, MJ; Meiering, EM; Holyoak, T Asymmetric Anchoring Is Required for Efficient O-Loop Opening and Closing in Cytosolic Phosphoenolpyruvate Carboxykinase. Biochemistry 56:2106-2115 (2017) [PubMed]  Article 
Target
Name:
Phosphoenolpyruvate carboxykinase, cytosolic [GTP] [H477R]
Synonyms:
PCKGC_RAT | Pck1 | Phosphoenolpyruvate carboxykinase (PEPCK H477R)
Type:
Enzyme
Mol. Mass.:
69434.03
Organism:
Rattus norvegicus (Rat)
Description:
Rat cytosolic PEPCK H477R mutant
Residue:
622
Sequence:
MPPQLHNGLDFSAKVIQGSLDSLPQEVRKFVEGNAQLCQPEYIHICDGSEEEYGRLLAHMQEEGVIRKLKKYDNCWLALTDPRDVARIESKTVIITQEQRDTVPIPKSGQSQLGRWMSEEDFEKAFNARFPGCMKGRTMYVIPFSMGPLGSPLAKIGIELTDSPYVVASMRIMTRMGTSVLEALGDGEFIKCLHSVGCPLPLKKPLVNNWACNPELTLIAHLPDRREIISFGSGYGGNSLLGKKCFALRIASRLAKEEGWLAEHMLILGITNPEGKKKYLAAAFPSACGKTNLAMMNPTLPGWKVECVGDDIAWMKFDAQGNLRAINPENGFFGVAPGTSVKTNPNAIKTIQKNTIFTNVAETSDGGVYWEGIDEPLAPGVTITSWKNKEWRPQDEEPCAHPNSRFCTPASQCPIIDPAWESPEGVPIEGIIFGGRRPAGVPLVYEALSWQHGVFVGAAMRSEATAAAEHKGKVIMRDPFAMRPFFGYNFGKYLAHWLSMAHRPAAKLPKIFHVNWFRKDKNGKFLWPGFGENSRVLEWMFGRIEGEDSAKLTPIGYVPKEDALNLKGLGDVNVEELFGISKEFWEKEVEEIDKYLEDQVNADLPYEIERELRALKQRISQM
  
Inhibitor
Name:
BDBM223201
Synonyms:
β-Sulfopyruvate
Type:
Small organic molecule
Emp. Form.:
C3H4O6S
Mol. Mass.:
168.125
SMILES:
OC(=O)C(=O)CS(O)(=O)=O
Structure:
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