Reaction Details Report a problem with these data
Target
Calcium/calmodulin-dependent protein kinase type IV [15-340]
Ligand
BDBM223207
Substrate
n/a
Meas. Tech.
Molecular Docking
Ki
1449.28±39.91 nM
Citation
 Jameel, E; Naz, H; Khan, P; Tarique, M; Kumar, J; Mumtazuddin, S; Ahamad, S; Islam, A; Ahmad, F; Hoda, N; Hassan, MI Design, synthesis, and biological evaluation of pyrimidine derivatives as potential inhibitors of human calcium/calmodulin-dependent protein kinase IV. Chem Biol Drug Des 89:741-754 (2017) [PubMed]  Article 
Target
Name:
Calcium/calmodulin-dependent protein kinase type IV [15-340]
Synonyms:
CAMK | CAMK-GR | CAMK4 | CAMKIV | Calcium/calmodulin- dependent protein kinase IV (CAMKIV) | KCC4_HUMAN
Type:
Enzyme
Mol. Mass.:
39277.89
Organism:
Homo sapiens (Human)
Description:
PDB 2W4O used as reference
Residue:
349
Sequence:
MHHHHHHSSGVDLGTENLYFQSMSSVTASAAPGTASLVPDYWIDGSNRDALSDFFEVESELGRGATSIVYRCKQKGTQKPYALKVLKKTVDKKIVRTEIGVLLRLSHPNIIKLKEIFETPTEISLVLELVTGGELFDRIVEKGYYSERDAADAVKQILEAVAYLHENGIVHRDLKPENLLYATPAPDAPLKIADFGLSKIVEHQVLMKTVCGTPGYCAPEILRGCAYGPEVDMWSVGIITYILLCGFEPFYDERGDQFMFRRILNCEYYFISPWWDEVSLNAKDLVRKLIVLDPKKRLTTFQALQHPWVTGKAANFVHMDTAQKKLQEFNARRKLKAAVKAVVASSRLG
  
Inhibitor
Name:
BDBM223207
Synonyms:
4-Methyl-7-((6-(quinolin-8-yloxy)pyrimidin-4-yl)oxy)-2H-chromen-2one (Molecule 4)
Type:
Small organic molecule
Emp. Form.:
C23H15N3O4
Mol. Mass.:
397.3829
SMILES:
Cc1cc(=O)oc2cc(Oc3cc(Oc4cccc5cccnc45)ncn3)ccc12
Structure:
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