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Target
Calcium/calmodulin-dependent protein kinase type IV [15-340]
Ligand
BDBM223208
Substrate
n/a
Meas. Tech.
Molecular Docking
Ki
1351.35±29.22 nM
Citation
 Jameel, E; Naz, H; Khan, P; Tarique, M; Kumar, J; Mumtazuddin, S; Ahamad, S; Islam, A; Ahmad, F; Hoda, N; Hassan, MI Design, synthesis, and biological evaluation of pyrimidine derivatives as potential inhibitors of human calcium/calmodulin-dependent protein kinase IV. Chem Biol Drug Des 89:741-754 (2017) [PubMed]  Article 
Target
Name:
Calcium/calmodulin-dependent protein kinase type IV [15-340]
Synonyms:
CAMK | CAMK-GR | CAMK4 | CAMKIV | Calcium/calmodulin- dependent protein kinase IV (CAMKIV) | KCC4_HUMAN
Type:
Enzyme
Mol. Mass.:
39277.89
Organism:
Homo sapiens (Human)
Description:
PDB 2W4O used as reference
Residue:
349
Sequence:
MHHHHHHSSGVDLGTENLYFQSMSSVTASAAPGTASLVPDYWIDGSNRDALSDFFEVESELGRGATSIVYRCKQKGTQKPYALKVLKKTVDKKIVRTEIGVLLRLSHPNIIKLKEIFETPTEISLVLELVTGGELFDRIVEKGYYSERDAADAVKQILEAVAYLHENGIVHRDLKPENLLYATPAPDAPLKIADFGLSKIVEHQVLMKTVCGTPGYCAPEILRGCAYGPEVDMWSVGIITYILLCGFEPFYDERGDQFMFRRILNCEYYFISPWWDEVSLNAKDLVRKLIVLDPKKRLTTFQALQHPWVTGKAANFVHMDTAQKKLQEFNARRKLKAAVKAVVASSRLG
  
Inhibitor
Name:
BDBM223208
Synonyms:
7-((6-((5-Methoxy-1H-benzo[d]imidazol-2-yl)thio)pyrimidin-4-yl)oxy)-4-methyl-2H-chromen-2-one (Molecule 5)
Type:
Small organic molecule
Emp. Form.:
C22H16N4O4S
Mol. Mass.:
432.452
SMILES:
COc1ccc2[nH]c(Sc3cc(Oc4ccc5c(C)cc(=O)oc5c4)ncn3)nc2c1
Structure:
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