Reaction Details Report a problem with these data
Target
Leukotriene C4 synthase
Ligand
BDBM223286
Substrate
LTC4
Meas. Tech.
In Vitro hLTC4 Synthase Enzyme Assay (Test A)
pH
7.8±n/a
IC50
39±n/a nM
Comments
extracted
Citation
Ronn, R; Lindh, CJ; Ringberg, E; Andersson, HB; Nilsson, P; Schaal, WR; Rosenschold, MM; Nikitidis, A; Nikitidis, G; Johannesson, P; Tyrcha, C Compounds and uses US Patent US20160326143 Publication Date 11/10/2016
More Info.:
Target
Name:
Leukotriene C4 synthase
Synonyms:
LTC4 synthase | LTC4S | LTC4S_HUMAN | Leukotriene-C(4) synthase
Type:
PROTEIN
Mol. Mass.:
16575.59
Organism:
Homo sapiens (Human)
Description:
ChEMBL_961179
Residue:
150
Sequence:
MKDEVALLAAVTLLGVLLQAYFSLQVISARRAFRVSPPLTTGPPEFERVYRAQVNCSEYFPLFLATLWVAGIFFHEGAAALCGLVYLFARLRYFQGYARSAQLRLAPLYASARALWLLVALAALGLLAHFLPAALRAALLGRLRTLLPWA
Inhibitor
Name:
BDBM223286
Synonyms:
(2-(1H-Tetrazol-5-yl)cyclopropyl)(5-((cyclopropylmethyl)(4-fluoronaphthalen-1-yl)amino)-3-methoxypyridin-2-yl)methanone | US20160326143, 61 | US9657001, 61
Type:
Small Organic Molecule
Emp. Form.:
C25H23FN6O2
Mol. Mass.:
458.4875
SMILES:
COc1cc(cnc1C(=O)C1CC1c1nnn[nH]1)N(CC1CC1)c1ccc(F)c2ccccc12