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Target
Ubiquitin carboxyl-terminal hydrolase 2 [258-605]
Ligand
BDBM223973
Substrate
n/a
Meas. Tech.
Ub-AMC-Hydrolysis Assay
IC50
5.8e+3± 7e+2 nM
Citation
 Magiera, K; Tomala, M; Kubica, K; De Cesare, V; Trost, M; Zieba, BJ; Kachamakova-Trojanowska, N; Les, M; Dubin, G; Holak, TA; Skalniak, L Lithocholic Acid Hydroxyamide Destabilizes Cyclin D1 and Induces G0/G1 Arrest by Inhibiting Deubiquitinase USP2a. Cell Chem Biol 24:458-470 (2017) [PubMed]  Article 
Target
Name:
Ubiquitin carboxyl-terminal hydrolase 2 [258-605]
Synonyms:
UBP2_HUMAN | UBP41 | USP2 | Ubiquitin-specific peptidase 2a (USP2a)
Type:
Enzyme
Mol. Mass.:
40094.16
Organism:
Homo sapiens (Human)
Description:
Hman USP2a (258-605 aa)
Residue:
348
Sequence:
MNSKSAQGLAGLRNLGNTCFMNSILQCLSNTRELRDYCLQRLYMRDLHHGSNAHTALVEEFAKLIQTIWTSSPNDVVSPSEFKTQIQRYAPRFVGYNQQDAQEFLRFLLDGLHNEVNRVTLRPKSNPENLDHLPDDEKGRQMWRKYLEREDSRIGDLFVGQLKSSLTCTDCGYCSTVFDPFWDLSLPIAKRGYPEVTLMDCMRLFTKEDVLDGDEKPTCCRCRGRKRCIKKFSIQRFPKILVLHLKRFSESRIRTSKLTTFVNFPLRDLDLREFASENTNHAVYNLYAVSNHSGTTMGGHYTAYCRSPGTGEWHTFNDSSVTPMSSSQVRTSDAYLLFYELASPPSRM
  
Inhibitor
Name:
BDBM223973
Synonyms:
LCAE
Type:
Small organic molecule
Emp. Form.:
C26H42O4
Mol. Mass.:
418.6093
SMILES:
COC(=O)C1CC[C@@]2(C)[C@H](CC[C@H]3[C@@H]4CC[C@H]([C@H](C)CCC(O)=O)[C@@]4(C)CC[C@H]23)C1 |r|
Structure:
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