Reaction Details Report a problem with these data
Target
Mas-related G-protein coupled receptor member X2
Ligand
BDBM224025
Substrate
n/a
Meas. Tech.
PRESTO-Tango Assay
pH
7.4±0
Temperature
303.15±0 K
EC50
2.1e+4±2.4e+4 nM
Citation
 Lansu, K; Karpiak, J; Liu, J; Huang, XP; McCorvy, JD; Kroeze, WK; Che, T; Nagase, H; Carroll, FI; Jin, J; Shoichet, BK; Roth, BL In silico design of novel probes for the atypical opioid receptor MRGPRX2. Nat Chem Biol 13:529-536 (2017) [PubMed]  Article 
Target
Name:
Mas-related G-protein coupled receptor member X2
Synonyms:
MRGPRX2 | MRGX2 | MRGX2_HUMAN | Mas-related G protein-coupled receptor X2 (MRGPRX2) | Mas-related G-protein coupled receptor member X2
Type:
GPCR
Mol. Mass.:
37104.79
Organism:
Homo sapiens (Human)
Description:
Q96LB1
Residue:
330
Sequence:
MDPTTPAWGTESTTVNGNDQALLLLCGKETLIPVFLILFIALVGLVGNGFVLWLLGFRMRRNAFSVYVLSLAGADFLFLCFQIINCLVYLSNFFCSISINFPSFFTTVMTCAYLAGLSMLSTVSTERCLSVLWPIWYRCRRPRHLSAVVCVLLWALSLLLSILEGKFCGFLFSDGDSGWCQTFDFITAAWLIFLFMVLCGSSLALLVRILCGSRGLPLTRLYLTILLTVLVFLLCGLPFGIQWFLILWIWKDSDVLFCHIHPVSVVLSSLNSSANPIIYFFVGSFRKQWRLQQPILKLALQRALQDIAEVDHSEGCFRQGTPEMSRSSLV
  
Inhibitor
Name:
BDBM224025
Synonyms:
Dynorphin A (1-17) | YGGFLRRXRPKLKWDNQ
Type:
Small organic molecule
Emp. Form.:
C99H155N31O23
Mol. Mass.:
2147.4839
SMILES:
CCC(C)C(NC(=O)C(CCCNC(N)=N)NC(=O)C(CCCNC(N)=N)NC(=O)C(CC(C)C)NC(=O)C(Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)C(N)Cc1ccc(O)cc1)C(=O)NC(CCCNC(N)=N)C(=O)N1CCCC1C(=O)NC(CCCCN)C(=O)NC(CC(C)C)C(=O)NC(CCCCN)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NC(CC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CCC(N)=O)C(O)=O
Structure:
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