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Target
Dual specificity protein phosphatase 5 [180-384]
Ligand
BDBM225233
Substrate
p-Nitrophenol (p-NPP)
Meas. Tech.
p-NPP Assay
Temperature
298.15±n/a K
IC50
5.100e+6± 1.900e+6 nM
Comments
extracted
Citation
 Neumann, TS; Span, EA; Kalous, KS; Bongard, R; Gastonguay, A; Lepley, MA; Kutty, RG; Nayak, J; Bohl, C; Lange, RG; Sarker, MI; Talipov, MR; Rathore, R; Ramchandran, R; Sem, DS Identification of inhibitors that target dual-specificity phosphatase 5 provide new insights into the binding requirements for the two phosphate pockets. BMC Biochem 16:19 (2015) [PubMed]  Article 
Target
Name:
Dual specificity protein phosphatase 5 [180-384]
Synonyms:
DUS5_HUMAN | DUSP5 | Dual-specificity phosphatase 5 phophatase domain (DUSP5 PD) | VH3
Type:
Protein
Mol. Mass.:
22525.06
Organism:
Homo sapiens (Human)
Description:
Human DUSP5 C-terminal phosphatase domain (180-384 aa)
Residue:
205
Sequence:
VEILPFLYLGSAYHASKCEFLANLHITALLNVSRRTSEACATHLHYKWIPVEDSHTADISSHFQEAIDFIDCVREKGGKVLVHCEAGISRSPTICMAYLMKTKQFRLKEAFDYIKQRRSMVSPNFGFMGQLLQYESEILPSTPNPQPPSCQGEAAGSSLIGHLQTLSPDMQGAYCTFPASVLAPVPTHSTVSELSRSPVATATSC
  
Inhibitor
Name:
BDBM225233
Synonyms:
RR505 | SM1842
Type:
Small organic molecule
Emp. Form.:
C12H6NO9S3
Mol. Mass.:
404.374
SMILES:
[O-]S(=O)(=O)c1ccc2[nH]c3c(cc(cc3c2c1)S([O-])(=O)=O)S([O-])(=O)=O
Structure:
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Substrate
Name:
BDBM31678
Synonyms:
p-nitrophenol
Type:
Small organic molecule
Emp. Form.:
C6H5NO3
Mol. Mass.:
139.1088
SMILES:
Oc1ccc(cc1)[N+]([O-])=O
Structure:
Search PDB for entries with ligand similarity: