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Target
Serine/threonine-protein kinase pim-1
Ligand
BDBM227245
Substrate
n/a
Meas. Tech.
PIM Kinase Binding Assay
pH
7.2±n/a
Temperature
298.15±n/a K
Ki
0.006±n/a nM
Comments
extracted
Citation
 Burch, J; Sun, M; Wang, X; Blackaby, W; Hodges, AJ; Sharpe, A Cyclic ether pyrazol-4-yl-heterocyclyl-carboxamide compounds and methods of use US Patent  US9328106 Publication Date 5/3/2016 
Target
Name:
Serine/threonine-protein kinase pim-1
Synonyms:
PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:
Protein
Mol. Mass.:
35681.82
Organism:
Homo sapiens (Human)
Description:
P11309
Residue:
313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
  
Inhibitor
Name:
BDBM227245
Synonyms:
US9328106, 196
Type:
Small organic molecule
Emp. Form.:
C27H29F4N5O4
Mol. Mass.:
563.5439
SMILES:
Cn1ncc(NC(=O)c2ccc(F)c(n2)-c2c(F)cc(cc2F)C2(O)CCOCC2)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 |r,wU:34.38,wD:31.34,36.40,(-6.15,4.02,;-6.15,2.48,;-7.39,1.58,;-6.92,.11,;-5.38,.11,;-4.61,-1.22,;-4.61,-2.76,;-5.94,-3.53,;-3.27,-3.53,;-3.27,-5.07,;-1.94,-5.84,;-.61,-5.07,;.73,-5.84,;-.61,-3.53,;-1.94,-2.76,;.73,-2.76,;.73,-1.22,;-.61,-.45,;2.06,-.45,;3.39,-1.22,;3.39,-2.76,;2.06,-3.53,;2.06,-5.07,;4.73,-.45,;4.73,-1.99,;6.06,-1.22,;7.39,-.45,;7.39,1.09,;6.06,1.86,;4.73,1.09,;-4.9,1.58,;-3.57,2.35,;-3.57,3.89,;-2.37,4.85,;-.86,4.51,;-.09,5.84,;-.2,3.12,;1.29,2.72,;-.86,1.73,;-2.37,1.39,)|
Structure:
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