Reaction Details Report a problem with these data
Target
Tumor necrosis factor
Ligand
BDBM228654
Substrate
n/a
Meas. Tech.
Surface Plasmon Resonance (SPR) Assay
pH
7±n/a
Kd
110±0.0 nM
Comments
extracted
Citation
 Ma, L; Gong, H; Zhu, H; Ji, Q; Su, P; Liu, P; Cao, S; Yao, J; Jiang, L; Han, M; Ma, X; Xiong, D; Luo, HR; Wang, F; Zhou, J; Xu, Y A novel small-molecule tumor necrosis factor a inhibitor attenuates inflammation in a hepatitis mouse model. J Biol Chem 289:12457-66 (2014) [PubMed]  Article 
Target
Name:
Tumor necrosis factor
Synonyms:
Cachectin | TNF | TNF-a | TNF-alpha | TNFA | TNFA_HUMAN | TNFSF2 | Tumor necrosis factor (TNF-alpha) | Tumor necrosis factor (TNFa) | Tumor necrosis factor alpha (TNFα) | Tumor necrosis factor ligand superfamily member 2 | Tumor necrosis factor, membrane form | Tumor necrosis factor, soluble form | tumor necrosis factor alpha
Type:
Enzyme
Mol. Mass.:
25645.11
Organism:
Homo sapiens (Human)
Description:
P01375
Residue:
233
Sequence:
MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGATTLFCLLHFGVIGPQREEFPRDLSLISPLAQAVRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELRDNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRETPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL
  
Inhibitor
Name:
BDBM228654
Synonyms:
(E)-4-(2-(4-chloro-3-nitrophenyl)) (C87)
Type:
Small organic molecule
Emp. Form.:
C24H15ClN6O3S
Mol. Mass.:
502.932
SMILES:
[O-][N+](=O)c1cc(N\N=C2\C(=O)N(N=C2c2ccccc2)c2nc(cs2)-c2ccccc2)ccc1Cl |c:12|
Structure:
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