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Target
Secreted cathepsin L 1
Ligand
BDBM232215
Substrate
n/a
Meas. Tech.
Cathepsin L Enzyme Assay
IC50
2.14e+4±n/a nM
Citation
Moran, BW; Anderson, FP; Ruth, DM; Fágáin, CO; Dalton, JP; Kenny, PT Fluorobenzoyl dipeptidyl derivatives as inhibitors of the Fasciola hepatica cysteine protease cathepsin L1. J Enzyme Inhib Med Chem 25:1-12 (2010) [PubMed] Article
More Info.:
Target
Name:
Secreted cathepsin L 1
Synonyms:
Cathepsin L1 (CL1) | Cysteine cathepsin L endoprotease
Type:
Protein
Mol. Mass.:
36773.95
Organism:
Fasciola hepatica (Liver fluke)
Description:
n/a
Residue:
326
Sequence:
MRLFVLAVLTVGVLGSNDDLWHQWKRMYNKEYNGADDQHRRNIWEKNVKHIQEHNLRHDLGLVTYTLGLNQFTDMTFEEFKAKYLTEMSRASDILSHGVPYEANNRAVPDKIDWRESGYVTEVKDQGNCGSCWAFSTTGTMEGQYMKNERTSISFSEQQLVDCSRPWGNNGCGGGLMENAYQYLKQFGLETESSYPYTAVEGQCRYNKQLGVAKVTGFYTVHSGSEVELKNLVGAEGPAAVAVDVESDFMMYRSGIYQSQTCSPLRVNHAVLAVGYGTQGGTDYWIVKNSWGLSWGERGYIRMVRNRGNMCGIASLASLPMVARFP
Inhibitor
Name:
BDBM232215
Synonyms:
N-4-fluorobenzoyl-L-leucine-γ-aminobutyric acid benzyl ester (11) | N-pentafluorobenzoyl-L-leucine-γ-aminobutyric acid benzyl ester (12)
Type:
Small organic molecule
Emp. Form.:
C23H27FN2O4
Mol. Mass.:
414.4699
SMILES:
CC(C)C[C@H](NC(=O)c1ccc(F)cc1)C(=O)NCCCC(=O)Oc1ccccc1 |r|