Target
Voltage-dependent calcium channel gamma-2 subunit
Ligand
BDBM292055
Substrate
n/a
Meas. Tech.
Biological Assays Calcium Flux Assay
pH
7.4±n/a
IC50
0.032±n/a nM
Comments
extracted
Citation
 Ameriks, MKLaforteza, BNSavall, BMWade, WSMeyer, STGyuris, M 3-aryl-2H-pyrazolo[4,3-b]pyridine compounds and their use as AMPA receptor modulators US Patent  US10100045 Publication Date 10/16/2018 
Target
Name:
Voltage-dependent calcium channel gamma-2 subunit
Synonyms:
CACNG2 | CCG2_HUMAN | Neuronal voltage-gated calcium channel gamma-2 subunit | TARP gamma-2 | Transmembrane AMPAR regulatory protein gamma-2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
35977.54
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
323
Sequence:
MGLFDRGVQMLLTTVGAFAAFSLMTIAVGTDYWLYSRGVCKTKSVSENETSKKNEEVMTHSGLWRTCCLEGNFKGLCKQIDHFPEDADYEADTAEYFLRAVRASSIFPILSVILLFMGGLCIAASEFYKTRHNIILSAGIFFVSAGLSNIIGIIVYISANAGDPSKSDSKKNSYSYGWSFYFGALSFIIAEMVGVLAVHMFIDRHKQLRATARATDYLQASAITRIPSYRYRYQRRSRSSSRSTEPSHSRDASPVGIKGFNTLPSTEISMYTLSRDPLKAATTPTATYNSDRDNSFLQVHNCIQKENKDSLHSNTANRRTTPV
  
Inhibitor
Name:
BDBM292055
Synonyms:
7-Chloro-5-(2-cyclobutyl-5-(trifluoromethyl)-2H-pyrazolo[4,3-b]pyridin-3-yl)indolin- | US10100045, Example 26
Type:
Small organic molecule
Emp. Form.:
C19H14ClF3N4O
Mol. Mass.:
406.789
SMILES:
FC(F)(F)c1ccc2nn(C3CCC3)c(-c3cc4CC(=O)Nc4c(Cl)c3)c2n1
Structure:
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