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Target
D(1A) dopamine receptor
Ligand
BDBM235769
Substrate
n/a
Meas. Tech.
Reception Binding Assay
Temperature
303.15±n/a K
Ki
320.11±n/a nM
IC50
648.23±n/a nM
Comments
extracted
Citation
 Liu, H; Xie, X; Zhen, X; Sun, H; Li, J; Zhu, L; Li, Z; Chen, Y; Jiang, H; Chen, K Hexahydrodibenzo[a,g]quinolizine compound, preparation method thereof, pharmaceutical composition and use thereof US Patent  US9359372 Publication Date 6/7/2016 
Target
Name:
D(1A) dopamine receptor
Synonyms:
DA D1 receptor | DOPAMINE D1 | DRD1 | DRD1_HUMAN | Dopamine D1 receptor | Dopamine D1 receptor (D1R) | Dopamine D1A
Type:
Enzyme
Mol. Mass.:
49303.43
Organism:
Homo sapiens (Human)
Description:
P21728
Residue:
446
Sequence:
MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLAETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKNCQTTTGNGKPVECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGSGETQPFCIDSNTFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPATNNAIETVSINNNGAAMFSSHHEPRGSISKECNLVYLIPHAVGSSEDLKKEEAAGIARPLEKLSPALSVILDYDTDVSLEKIQPITQNGQHPT
  
Inhibitor
Name:
BDBM235769
Synonyms:
US9359372, DC037006
Type:
Small organic molecule
Emp. Form.:
C22H27NO5
Mol. Mass.:
385.4535
SMILES:
COc1cc2CCN3Cc4c(C[C@H]3c2cc1OC)cc(OC)c(OC)c4OC |r|
Structure:
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