Reaction Details Report a problem with these data
Target
Carbonic anhydrase 1
Ligand
BDBM237182
Substrate
n/a
Meas. Tech.
Esterase Activity Assay
pH
7.4±0
Temperature
298.15±0 K
Ki
8.61e+4±n/a nM
IC50
7.94e+4±n/a nM
Citation
 Cankaya, M; Aktas, M; Kuzucu, M; Gül, Ä°; Coban, TA Effects of some drugs on human cord blood erythrocyte carbonic anhydrases I and II: an in vitro study. J Enzyme Inhib Med Chem 27:641-5 (2012) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 1
Synonyms:
CA-I | CA1 | CAB | CAH1_HUMAN | Carbonate dehydratase I | Carbonic anhydrase | Carbonic anhydrase 1 (CA I) | Carbonic anhydrase 1 (CA-I) | Carbonic anhydrase 1 (Recombinant CA I) | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase B | Carbonic anhydrase I | Carbonic anhydrase I (CA I) | Carbonic anhydrase I (CA-I) | Carbonic anhydrase I (CAI) | Carbonic anhydrase I (hCA I) | Carbonic anhydrase isoenzyme I (hCA I) | hCA
Type:
Enzyme
Mol. Mass.:
28873.37
Organism:
Homo sapiens (Human)
Description:
P00915
Residue:
261
Sequence:
MASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF
  
Inhibitor
Name:
BDBM237182
Synonyms:
Ceftizoxime
Type:
Small organic molecule
Emp. Form.:
C13H13N5O5S2
Mol. Mass.:
383.403
SMILES:
CO\N=C(/C(=O)N[C@H]1[C@H]2SCC=C(N2C1=O)C(O)=O)c1csc(N)n1 |c:11|
Structure:
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