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Target
Serine/threonine-protein kinase pim-2
Ligand
BDBM238445
Substrate
n/a
Meas. Tech.
Homogeneous Time Resolved Fluorescence Assay (HTRF)
pH
7±n/a
Temperature
295.15±n/a K
IC50
1.9±n/a nM
Comments
extracted
Citation
 Cee, V; Chavez, Jr., F; Chen, JJ; Harrington, EH; Herberich, B; Jackson, CL; Lanman, BA; Nguyen, TT; Norman, MH; Pettus, LH; Reed, AB; Smith, AL; Tamayo, NA; Tasker, A; Wang, H; Wu, B; Wurz, R Amides as pim inhibitors US Patent  US9394297 Publication Date 7/19/2016 
Target
Name:
Serine/threonine-protein kinase pim-2
Synonyms:
PIM2 | PIM2_HUMAN | Pim-2h | Serine/threonine-protein kinase (PIM2) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase pim-2 (PIM2)
Type:
Serine/threonine-protein kinase
Mol. Mass.:
34185.93
Organism:
Homo sapiens (Human)
Description:
Q9P1W9
Residue:
311
Sequence:
MLTKPLQGPPAPPGTPTPPPGGKDREAFEAEYRLGPLLGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPLEVALLWKVGAGGGHPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEKGPLGEGPSRCFFGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFGSGALLHDEPYTDFDGTRVYSPPEWISRHQYHALPATVWSLGILLYDMVCGDIPFERDQEILEAELHFPAHVSPDCCALIRRCLAPKPSSRPSLEEILLDPWMQTPAEDVPLNPSKGGPAPLAWSLLP
  
Inhibitor
Name:
BDBM238445
Synonyms:
US9394297, 72
Type:
Small organic molecule
Emp. Form.:
C20H21N5O2
Mol. Mass.:
363.413
SMILES:
Cc1nc2cccc(-c3cc4c(CCNC4=O)[nH]3)c2nc1NC1CC(O)C1 |(5.33,-3.08,;4,-2.31,;2.67,-3.08,;1.33,-2.31,;,-3.08,;-1.33,-2.31,;-1.33,-.77,;;,1.54,;1.25,2.45,;.77,3.91,;-.77,3.91,;-1.54,5.24,;-.77,6.58,;.77,6.58,;1.54,5.24,;3.08,5.24,;-1.25,2.45,;1.33,-.77,;2.67,,;4,-.77,;5.33,,;6.67,-.77,;8.16,-.37,;8.55,-1.86,;9.89,-2.63,;7.07,-2.26,)|
Structure:
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