Reaction Details Report a problem with these data
Target
Hexokinase-4
Ligand
BDBM239065
Substrate
n/a
Meas. Tech.
Activation Assay
pH
7.1±n/a
EC50
2000±n/a nM
Citation
 Kang, X; Long, W; Ma, C; Wang, Y; Shen, X; Hu, Y; Tan, F; Wang, Y Compound for increasing kinase active and application thereof US Patent  US9409900 Publication Date 8/9/2016 
Target
Name:
Hexokinase-4
Synonyms:
Gck | Gk | Glucokinase | HK IV | HK4 | HXK4_MOUSE | Hexokinase-4 | Hexokinase-D
Type:
Enzyme
Mol. Mass.:
52075.40
Organism:
Mus musculus (Mouse)
Description:
P52792
Residue:
465
Sequence:
MLDDRARMEATKKEKVEQILAEFQLQEEDLKKVMSRMQKEMDRGLKLETHQEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEAGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNIVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGNSGELDEFLLEYDRMVDESSVNPGQQLYEKIIGGKYMGELVRLVLLKLVEENLLFHGEASEQLRTRGAFETRFVSQVESDSGDRRQILNILSTLGLRPSVADCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPNCEITFIESEEGSGRGAALVSAVACKKACMLGQ
  
Inhibitor
Name:
BDBM239065
Synonyms:
US9409900, 6
Type:
Small organic molecule
Emp. Form.:
C23H22N4O6S
Mol. Mass.:
482.509
SMILES:
CS(=O)(=O)c1ccc(Oc2ccc(Nc3ccc(cn3)C(O)=O)cc2CN2CCCC2=O)cn1
Structure:
Search PDB for entries with ligand similarity: