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Target
Mu-type opioid receptor
Ligand
BDBM239920
Substrate
n/a
Meas. Tech.
Binding Assay
Temperature
298.15±n/a K
Ki
235±n/a nM
Comments
extracted
Citation
 Nolte, B; Schröder, W; Linz, K; Englberger, W; Schick, H; Graubaum, H; Braun, B; Ozegowski, S; Bálint, J; Sonnenschein, H Substituted 4-aminocyclohexane derivatives US Patent  US9403767 Publication Date 8/2/2016 
Target
Name:
Mu-type opioid receptor
Synonyms:
M-OR-1 | MOP | MOR-1 | MOR1 | MUOR1 | Mu Opioid Receptor | Mu opiate receptor | OPIATE Mu | OPRM1 | OPRM_HUMAN | hMOP | mu-type opioid receptor isoform MOR-1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44789.51
Organism:
Homo sapiens (Human)
Description:
P35372
Residue:
400
Sequence:
MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM239920
Synonyms:
US9403767, 96
Type:
Small organic molecule
Emp. Form.:
C27H33FN2O2
Mol. Mass.:
436.5615
SMILES:
CCCC(=O)OC1(CCC(CC1)(N(C)C)c1cccc(F)c1)c1[nH]c2ccccc2c1C |(-7.7,1.14,;-6.25,1.67,;-5.07,.68,;-3.63,1.2,;-3.36,2.72,;-2.45,.21,;-2.71,-1.3,;-4.16,-.78,;-5.34,-1.77,;-5.07,-3.28,;-3.63,-3.81,;-2.45,-2.82,;-5.34,-4.8,;-4.16,-5.79,;-6.79,-5.33,;-6.61,-3.28,;-7.38,-4.62,;-8.92,-4.62,;-9.69,-3.28,;-8.92,-1.95,;-9.69,-.62,;-7.38,-1.95,;-1.17,-1.3,;-.27,-.06,;1.2,-.53,;2.53,.24,;3.86,-.53,;3.86,-2.07,;2.53,-2.84,;1.2,-2.07,;-.27,-2.55,;-.74,-4.01,)|
Structure:
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