Reaction Details
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Tubulin alpha chain
Ligand
BDBM50375664
Substrate
n/a
Meas. Tech.
Assembly Assay
pH
6.9±n/a
Temperature
303.15±n/a K
IC50
6000±n/a nM
Comments
extracted
Citation
Bakare, O; Lee, CM; Brandy, Y; Khraiwesh, MH Method for inhibiting Trypanosoma cruzi US Patent US9422231 Publication Date 8/23/2016 More Info.:
Target
Name:
Tubulin alpha chain
Synonyms:
TBA_TRYCR | Tubulin
Type:
Enzyme
Mol. Mass.:
49709.04
Organism:
Trypanosoma cruzi
Description:
Q27352
Residue:
451
Sequence:
MREAICIHIGQAGCQVGNACWELFCLEHGIQPDGAMPSDKTIGVEDDAFNTFFSETGAGKHVPRAVFLDLEPTVVDEIRTGTYRQLFHPEQLISGKEDAANNYARGHYTIGKEIVDLCLDRIRKLADNCTGLQGFLVYHAVGGGTGSGLGALLLERLSVDYGKKSKLGYTVYPSPQVSTAVVEPYNSVLSTHSLLEHTDVAAMLDNEAIYDLTRANLDIERPTYTNLNRLIGQVVSALTASLRFDGALNVDLTEFQTNLVPYPRIHFVLTTYAPVISAEKAYHEQLSVSEISNAVFEPASMMTKCDPRHGKYMACCLMYRGDVVPKDVNAAVATIKTKRTIQFVDWSPTGFKCGINYQPPTVVPGGDLAKVQRAVCMIANSTAIAEVFARIDHKFDLMYSKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEEVGAESADMEGEEDVEEY
Inhibitor
Name:
BDBM50375664
Synonyms:
CHEMBL404939 | US9422231, IMDNQ1
Type:
Small organic molecule
Emp. Form.:
C14H8ClNO4
Mol. Mass.:
289.671
SMILES:
ClC1=C(N2C(=O)CCC2=O)C(=O)c2ccccc2C1=O |c:1|
Structure:
