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Target
Genome polyprotein [1973-2420]
Ligand
BDBM241835
Substrate
n/a
Meas. Tech.
Luciferase Assay
EC50
2.067±n/a nM
Citation
 Zhang, J; Zhang, Y; Xie, H; Ren, Q; Hu, B; Fu, C; Wu, X; Li, S; Wang, C; Zhang, Z Spiro ring compound as hepatitis C virus (HCV) inhibitor and uses thereof US Patent  US9416139 Publication Date 8/16/2016 
Target
Name:
Genome polyprotein [1973-2420]
Synonyms:
Non-structural protein 5A (NS5A) | POLG_HCV1
Type:
Enzyme
Mol. Mass.:
48946.19
Organism:
Hepatitis C virus genotype 1a (HCV)
Description:
aa 1973-2420
Residue:
448
Sequence:
SGSWLRDIWDWICEVLSDFKTWLKAKLMPQLPGIPFVSCQRGYKGVWRVDGIMHTRCHCGAEITGHVKNGTMRIVGPRTCRNMWSGTFPINAYTTGPCTPLPAPNYTFALWRVSAEEYVEIRQVGDFHYVTGMTTDNLKCPCQVPSPEFFTELDGVRLHRFAPPCKPLLREEVSFRVGLHEYPVGSQLPCEPEPDVAVLTSMLTDPSHITAEAAGRRLARGSPPSVASSSASQLSAPSLKATCTANHDSPDAELIEANLLWRQEMGGNITRVESENKVVILDSFDPLVAEEDEREISVPAEILRKSRRFAQALPVWARPDYNPPLVETWKKPDYEPPVVHGCPLPPPKSPPVPPPRKKRTVVLTESTLSTALAELATRSFGSSSTSGITGDNTTTSSEPAPSGCPPDSDAESYSSMPPLEGEPGDPDLSDGSWSTVSSEANAEDVVCC
  
Inhibitor
Name:
BDBM241835
Synonyms:
US9416139, 13
Type:
Small organic molecule
Emp. Form.:
C58H58N8O7
Mol. Mass.:
979.1305
SMILES:
COC(=O)N[C@H](C(=O)N1CCC[C@H]1c1ncc([nH]1)-c1ccc(cc1)-c1ccc(c2CC3(CCCC3)Cc12)-c1ccc2nc([nH]c(=O)c2c1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)c1ccccc1)c1ccccc1 |r|
Structure:
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