Reaction Details Report a problem with these data
Target
Serum paraoxonase/arylesterase 1
Ligand
BDBM243043
Substrate
n/a
Meas. Tech.
Enzyme Activity Assay
IC50
1.74e+5±n/a nM
Citation
 Akbaba, Y; Türkes, C; Polat, L; Söyüt, H; Sahin, E; Menzek, A; Göksu, S; Beydemir, S Synthesis and paroxonase activities of novel bromophenols. J Enzyme Inhib Med Chem 28:1073-9 (2013) [PubMed]  Article 
Target
Name:
Serum paraoxonase/arylesterase 1
Synonyms:
A-esterase 1 | Aromatic esterase 1 | K-45 | PON | PON 1 | PON1 | PON1_HUMAN | Paraoxonase (PON1) | Paraoxonase (hPON1) | Paraoxonase 1 (PON1) | Serum aryldialkylphosphatase 1 | Serum paraoxonase 1 (PON1)
Type:
Enzyme
Mol. Mass.:
39719.73
Organism:
Homo sapiens (Human)
Description:
P27169
Residue:
355
Sequence:
MAKLIALTLLGMGLALFRNHQSSYQTRLNALREVQPVELPNCNLVKGIETGSEDLEILPNGLAFISSGLKYPGIKSFNPNSPGKILLMDLNEEDPTVLELGITGSKFDVSSFNPHGISTFTDEDNAMYLLVVNHPDAKSTVELFKFQEEEKSLLHLKTIRHKLLPNLNDIVAVGPEHFYGTNDHYFLDPYLQSWEMYLGLAWSYVVYYSPSEVRVVAEGFDFANGINISPDGKYVYIAELLAHKIHVYEKHANWTLTPLKSLDFNTLVDNISVDPETGDLWVGCHPNGMKIFFYDSENPPASEVLRIQNILTEEPKVTQVYAENGTVLQGSTVASVYKGKLLIGTVFHKALYCEL
  
Inhibitor
Name:
BDBM243043
Synonyms:
(2,3-dibromo-5,6-dimethoxyphenyl)(3,4-dimethoxyphenyl)methanone (7)
Type:
Small organic molecule
Emp. Form.:
C17H16Br2O5
Mol. Mass.:
460.114
SMILES:
COc1ccc(cc1OC)C(=O)c1c(Br)c(Br)cc(OC)c1OC
Structure:
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