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Target
Transthyretin
Ligand
BDBM50197883
Substrate
n/a
Meas. Tech.
In vitro evaluation of inhibitory activity against WT-TTR
IC50
3100±150 nM
Citation
 Vieira Simões, CJ; Lourenço de Almeida, ZC; Vasconcelos Dias de Pinho e Melo, TM; Pontes Meireles Ferreira de Brito, RM; Silva Costa, DC; Cabral Cardoso Lopes, AL Bis-furan derivatives as transthyretin (TTR) stabilizers and amyloid inhibitors for the treatment of familial amyloid polyneuropathy (FAP) US Patent  US10377729 Publication Date 8/13/2019 
Target
Name:
Transthyretin
Synonyms:
ATTR | PALB | Prealbumin | TBPA | TTHY_HUMAN | TTR | Transthyretin (TTR)
Type:
Enzyme
Mol. Mass.:
15884.31
Organism:
Homo sapiens (Human)
Description:
P02766
Residue:
147
Sequence:
MASHRLLLLCLAGLVFVSEAGPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNPKE
  
Inhibitor
Name:
BDBM50197883
Synonyms:
CHEBI:78538 | FX-1006 | Tafamidis | US10377729, Compound Tafamidis | Vyndaqel
Type:
Small organic molecule
Emp. Form.:
C14H7Cl2NO3
Mol. Mass.:
308.116
SMILES:
OC(=O)c1ccc2nc(oc2c1)-c1cc(Cl)cc(Cl)c1
Structure:
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