Reaction Details Report a problem with these data
Target
Epoxide hydrolase
Ligand
BDBM25738
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
23.0±n/a nM
Citation
 Guedes, AG; Hammock, BD; Morisseau, C Treatment of inflammatory disorders in non-human mammals US Patent  US10383835 Publication Date 8/20/2019 
Target
Name:
Epoxide hydrolase
Synonyms:
EPHX1
Type:
Enzyme
Mol. Mass.:
48577.06
Organism:
Equus caballus (Horse)
Description:
A0A5F5PR84
Residue:
462
Sequence:
MMTSLRVMWLEILLTSVLGFVIYWFVSRDKEETLPLEDGWWGPGSRPTGREDESIRPFKVETSDEEINDLHQRIDKARLTPPLEDSRFHYGFNSNYLKQIVSYWRNEFDWKKQVEILNRYPHFKTKIEGLDIHFIHVKPPQLPSGRTPKPLLMVHGWPGSFYEFYKIIPFLTDPKSHGLGDEHVFEVICPCIPGYGFSEASSKKGFNTVATARIFYKLMLRLGFQEFYVQGGDWGALICTNIAQLVPSHVKGLHLNMAFVLRSFYTLTLPLGRHFAGLFGYTHKDVELMYPFKEKIFYSLMRESGYMHIQATKPDTVGCALNDSPVGLAAYILEKFSTWTKSEFRDLEDGGLERKFSLDDLLTNIMLYWTTGSITSSQRFYKENLGQGYMAHKHERMKVYVPTGFAAFPCELLHAPENWVKFKYPKLISYSYMPRGGHFAAFEEPQLLAQDIRKFVGLLERQ
  
Inhibitor
Name:
BDBM25738
Synonyms:
1-adamantan-1-yl-3-{5-[2-(2-ethoxyethoxy)ethoxy]pentyl}urea | CHEMBL242655 | US10383835, Compound 950 | Urea-based compound, 19
Type:
Small organic molecule
Emp. Form.:
C22H40N2O4
Mol. Mass.:
396.564
SMILES:
CCOCCOCCOCCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2 |TLB:25:20:27:24.23.26,25:24:20.21.19:27,THB:23:22:19:24.25.26,23:24:19:22.21.27|
Structure:
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