Reaction Details Report a problem with these data
Target
Histone deacetylase 11
Ligand
BDBM50273553
Substrate
n/a
Meas. Tech.
HDAC Inhibition Assays
IC50
3.00±n/a nM
Citation
 Lee, J; Barczak, N; Escobedo, JA; Conti, C; Han, B; Lancia, Jr., DR; Liu, C; Martin, MW; Ng, PY; Rudnitskaya, A; Thomason, JR; Zheng, X Methods using HDAC11 inhibitors US Patent  US10508088 Publication Date 12/17/2019 
Target
Name:
Histone deacetylase 11
Synonyms:
HD11 | HDA11_HUMAN | HDAC11 | Human HDAC11
Type:
Chromatin regulator; hydrolase; repressor
Mol. Mass.:
39187.66
Organism:
Homo sapiens (Human)
Description:
Q96DB2
Residue:
347
Sequence:
MLHTTQLYQHVPETRWPIVYSPRYNITFMGLEKLHPFDAGKWGKVINFLKEEKLLSDSMLVEAREASEEDLLVVHTRRYLNELKWSFAVATITEIPPVIFLPNFLVQRKVLRPLRTQTGGTIMAGKLAVERGWAINVGGGFHHCSSDRGGGFCAYADITLAIKFLFERVEGISRATIIDLDAHQGNGHERDFMDDKRVYIMDVYNRHIYPGDRFAKQAIRRKVELEWGTEDDEYLDKVERNIKKSLQEHLPDVVVYNAGTDILEGDRLGGLSISPAGIVKRDELVFRMVRGRRVPILMVTSGGYQKRTARIIADSILNLFGLGLIGPESPSVSAQNSDTPLLPPAVP
  
Inhibitor
Name:
BDBM50273553
Synonyms:
CHEMBL4127020 | US10508088, ID HDTK028 | US11535607, Example 17-1
Type:
Small organic molecule
Emp. Form.:
C19H17F3N4O2
Mol. Mass.:
390.3591
SMILES:
CC1(C)N(Cc2c1cccc2C(=O)NO)c1nc2ccc(cc2[nH]1)C(F)(F)F
Structure:
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