Reaction Details Report a problem with these data
Target
Casein kinase I isoform delta
Ligand
BDBM6870
Substrate
CK1 Peptide Substrate
Meas. Tech.
Kinase Inhibition Assay
IC50
570±n/a nM
Citation
 Lin, R; Connolly, PJ; Huang, S; Wetter, SK; Lu, Y; Murray, WV; Emanuel, SL; Gruninger, RH; Fuentes-Pesquera, AR; Rugg, CA; Middleton, SA; Jolliffe, LK 1-Acyl-1H-[1,2,4]triazole-3,5-diamine analogues as novel and potent anticancer cyclin-dependent kinase inhibitors: synthesis and evaluation of biological activities. J Med Chem 48:4208-11 (2005) [PubMed]  Article 
Target
Name:
Casein kinase I isoform delta
Synonyms:
CK1, delta | Casein kinase 1 Delta | Casein kinase I delta | Casein kinase I isoform delta | Csnk1d | Hckid | KC1D_RAT | casein kinase 1, delta
Type:
Enzyme
Mol. Mass.:
47342.73
Organism:
Rattus norvegicus (rat)
Description:
Q06486
Residue:
415
Sequence:
MELRVGNRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVKTKHPQLHIESKIYKMMQGGVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFATYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLKFGASRAADDAERERRDREERLRHSRNPATRGLPSTASGRLRGTQEVAPPTPLTPTSHTANTSPRPVSGMERERKVSMRLHRGAPVNVSSSDLTGRQDTSRMSTSQIPGRVASSGLQSVVHR
  
Inhibitor
Name:
BDBM6870
Synonyms:
1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3f | 4-({5-amino-1-[(3-methylthiophen-2-yl)carbonyl]-1H-1,2,4-triazol-3-yl}amino)benzene-1-sulfonamide | 4-[[5-Amino-1-[(3-methyl-2-thienyl)carbonyl]-1H-1,2,4-triazol-3-yl]amino]-benzenesulfonamide
Type:
Small organic molecule
Emp. Form.:
C14H14N6O3S2
Mol. Mass.:
378.429
SMILES:
Cc1ccsc1C(=O)n1nc(Nc2ccc(cc2)S(N)(=O)=O)nc1N
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
CK1 Peptide Substrate
Synonyms:
n/a
Type:
Peptide
Mol. Mass.:
3083.59
Organism:
n/a
Description:
n/a
Residue:
28
Sequence:
ITINKRRRALSPHSPHVASLPGLAMIDE