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Target
Tyrosine-protein kinase TXK
Ligand
BDBM434525
Substrate
n/a
Meas. Tech.
Kinase Inhibition Assay
EC50
>100±n/a nM
Citation
 Laurent, A; Rose, Y; Morris, SJ Benzimidazoles derivatives as Tec kinases family inhibitors US Patent  US10562893 Publication Date 2/18/2020 
Target
Name:
Tyrosine-protein kinase TXK
Synonyms:
PTK4 | Protein-tyrosine kinase 4 | RLK | Resting lymphocyte kinase | TXK | TXK_HUMAN | Tyrosine-protein kinase TXK (TXK)
Type:
Protein
Mol. Mass.:
61268.80
Organism:
Homo sapiens (Human)
Description:
P42681
Residue:
527
Sequence:
MILSSYNTIQSVFCCCCCCSVQKRQMRTQISLSTDEELPEKYTQRRRPWLSQLSNKKQSNTGRVQPSKRKPLPPLPPSEVAEEKIQVKALYDFLPREPCNLALRRAEEYLILEKYNPHWWKARDRLGNEGLIPSNYVTENKITNLEIYEWYHRNITRNQAEHLLRQESKEGAFIVRDSRHLGSYTISVFMGARRSTEAAIKHYQIKKNDSGQWYVAERHAFQSIPELIWYHQHNAAGLMTRLRYPVGLMGSCLPATAGFSYEKWEIDPSELAFIKEIGSGQFGVVHLGEWRSHIQVAIKAINEGSMSEEDFIEEAKVMMKLSHSKLVQLYGVCIQRKPLYIVTEFMENGCLLNYLRENKGKLRKEMLLSVCQDICEGMEYLERNGYIHRDLAARNCLVSSTCIVKISDFGMTRYVLDDEYVSSFGAKFPIKWSPPEVFLFNKYSSKSDVWSFGVLMWEVFTEGKMPFENKSNLQVVEAISEGFRLYRPHLAPMSIYEVMYSCWHEKPEGRPTFAELLRAVTEIAETW
  
Inhibitor
Name:
BDBM434525
Synonyms:
US10562893, Compound 27
Type:
Small organic molecule
Emp. Form.:
C29H32N6O2
Mol. Mass.:
496.6034
SMILES:
C[C@H](NCc1ccc2n(c(NC(=O)c3ccccn3)nc2c1)-c1cccc(NC(=O)C=C)c1)C(C)(C)C |r|
Structure:
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