Reaction Details Report a problem with these data
Target
Sigma intracellular receptor 2
Ligand
BDBM349518
Substrate
n/a
Meas. Tech.
Competitive Radioligand Binding Assay
Ki
0.530±n/a nM
Citation
 Rishton, GM; Catalano, SM; Look, GC Isoindoline compositions and methods for treating neurodegenerative disease US Patent  US10611728 Publication Date 4/7/2020 
Target
Name:
Sigma intracellular receptor 2
Synonyms:
MAC30 | Meningioma-associated protein 30 | S2R | SGMR2_HUMAN | Sigma-2 receptor | Sigma2 receptor | TMEM97 | Transmembrane protein 97
Type:
Protein
Mol. Mass.:
20857.20
Organism:
Homo sapiens (Human)
Description:
Q5BJF2
Residue:
176
Sequence:
MGAPATRRCVEWLLGLYFLSHIPITLFMDLQAVLPRELYPVEFRNLLKWYAKEFKDPLLQEPPAWFKSFLFCELVFQLPFFPIATYAFLKGSCKWIRTPAIIYSVHTMTTLIPILSTFLFEDFSKASGFKGQRPETLHERLTLVSVYAPYLLIPFILLIFMLRSPYYKYEEKRKKK
  
Inhibitor
Name:
BDBM349518
Synonyms:
US10207991, Ex. Cpd. No. 34 | US10611728, Example Compound 34 | US11691947, Example 34
Type:
Small organic molecule
Emp. Form.:
C21H26FNO2
Mol. Mass.:
343.435
SMILES:
COc1cc2CN(Cc2cc1OC)C(C)(C)CCc1ccc(F)cc1
Structure:
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