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Target
Tyrosyl-DNA phosphodiesterase 2
Ligand
BDBM437697
Substrate
n/a
Meas. Tech.
Biochemical Potency
IC50
35.0±0.2 nM
Citation
 Wang, Z; Kankanala, J; Pommier, Y Compounds for cancer chemotherapeutic sensitization US Patent  US10617706 Publication Date 4/14/2020 
Target
Name:
Tyrosyl-DNA phosphodiesterase 2
Synonyms:
EAP2 | EAPII | ETS1-associated protein 2 | ETS1-associated protein II | TDP2 | TRAF and TNF receptor-associated protein | TTRAP | TYDP2_HUMAN | Tyr-DNA phosphodiesterase 2 | Tyrosyl-DNA phosphodiesterase 2 | Tyrosyl-DNA phosphodiesterase 2 (hTDP2) | Tyrosyl-RNA phosphodiesterase | VPg unlinkase | hTDP2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
40916.54
Organism:
Homo sapiens (Human)
Description:
gi_23510348
Residue:
362
Sequence:
MELGSCLEGGREAAEEEGEPEVKKRRLLCVEFASVASCDAAVAQCFLAENDWEMERALNSYFEPPVEESALERRPETISEPKTYVDLTNEETTDSTTSKISPSEDTQQENGSMFSLITWNIDGLDLNNLSERARGVCSYLALYSPDVIFLQEVIPPYYSYLKKRSSNYEIITGHEEGYFTAIMLKKSRVKLKSQEIIPFPSTKMMRNLLCVHVNVSGNELCLMTSHLESTRGHAAERMNQLKMVLKKMQEAPESATVIFAGDTNLRDREVTRCGGLPNNIVDVWEFLGKPKHCQYTWDTQMNSNLGITAACKLRFDRIFFRAAAEEGHIIPRSLDLLGLEKLDCGRFPSDHWGLLCNLDIIL
  
Inhibitor
Name:
BDBM437697
Synonyms:
US10617706, Example 131
Type:
Small organic molecule
Emp. Form.:
C25H17N5O4
Mol. Mass.:
451.4336
SMILES:
NC(=O)c1cccc(c1)N1C(=O)NC2N(c3ccc(O)cc3)c3cc(ccc3C=C2C1=O)C#N |c:31|
Structure:
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