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Target
Histone-lysine N-methyltransferase SMYD3
Ligand
BDBM321290
Substrate
n/a
Meas. Tech.
SMYD3 Enzyme Assays on MEKK2 Protein Substrate
IC50
33495±n/a nM
Citation
 Chesworth, R; Foley, MA; Kuntz, KW; Mitchell, LH; Petter, JC; Schwartz, CE Isoxazole carboxamides as irreversible SMYD inhibitors US Patent  US10669243 Publication Date 6/2/2020 
Target
Name:
Histone-lysine N-methyltransferase SMYD3
Synonyms:
SET and MYND domain-containing protein 3 | SMYD3 | SMYD3_HUMAN | ZMYND1 | ZNFN3A1 | Zinc finger MYND domain-containing protein 1
Type:
Enzyme
Mol. Mass.:
49101.22
Organism:
Homo sapiens (Human)
Description:
Q9H7B4-2
Residue:
428
Sequence:
MEPLKVEKFATAKRGNGLRAVTPLRPGELLFRSDPLAYTVCKGSRGVVCDRCLLGKEKLMRCSQCRVAKYCSAKCQKKAWPDHKRECKCLKSCKPRYPPDSVRLLGRVVFKLMDGAPSESEKLYSFYDLESNINKLTEDKKEGLRQLVMTFQHFMREEIQDASQLPPAFDLFEAFAKVICNSFTICNAEMQEVGVGLYPSISLLNHSCDPNCSIVFNGPHLLLRAVRDIEVGEELTICYLDMLMTSEERRKQLRDQYCFECDCFRCQTQDKDADMLTGDEQVWKEVQESLKKIEELKAHWKWEQVLAMCQAIISSNSERLPDINIYQLKVLDCAMDACINLGLLEEALFYGTRTMEPYRIFFPGSHPVRGVQVMKVGKLQLHQGMFPQAMKNLRLAFDIMRVTHGREHSLIEDLILLLEECDANIRAS
  
Inhibitor
Name:
BDBM321290
Synonyms:
N-(1-(2-chloroacetyl)piperidin-4-yl)-5- cyclopropylisoxazole-3-carboxamide | US10179773, Compound 4 | US10669243, Compound 4
Type:
Small organic molecule
Emp. Form.:
C14H18ClN3O3
Mol. Mass.:
311.764
SMILES:
ClCC(=O)N1CCC(CC1)NC(=O)c1cc(on1)C1CC1
Structure:
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