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Target
Histone-lysine N-methyltransferase SMYD3
Ligand
BDBM321293
Substrate
n/a
Meas. Tech.
SMYD3 Enzyme Assays on MEKK2 Protein Substrate
IC50
3676±n/a nM
Citation
 Chesworth, R; Foley, MA; Kuntz, KW; Mitchell, LH; Petter, JC; Schwartz, CE Isoxazole carboxamides as irreversible SMYD inhibitors US Patent  US10669243 Publication Date 6/2/2020 
Target
Name:
Histone-lysine N-methyltransferase SMYD3
Synonyms:
SET and MYND domain-containing protein 3 | SMYD3 | SMYD3_HUMAN | ZMYND1 | ZNFN3A1 | Zinc finger MYND domain-containing protein 1
Type:
Enzyme
Mol. Mass.:
49101.22
Organism:
Homo sapiens (Human)
Description:
Q9H7B4-2
Residue:
428
Sequence:
MEPLKVEKFATAKRGNGLRAVTPLRPGELLFRSDPLAYTVCKGSRGVVCDRCLLGKEKLMRCSQCRVAKYCSAKCQKKAWPDHKRECKCLKSCKPRYPPDSVRLLGRVVFKLMDGAPSESEKLYSFYDLESNINKLTEDKKEGLRQLVMTFQHFMREEIQDASQLPPAFDLFEAFAKVICNSFTICNAEMQEVGVGLYPSISLLNHSCDPNCSIVFNGPHLLLRAVRDIEVGEELTICYLDMLMTSEERRKQLRDQYCFECDCFRCQTQDKDADMLTGDEQVWKEVQESLKKIEELKAHWKWEQVLAMCQAIISSNSERLPDINIYQLKVLDCAMDACINLGLLEEALFYGTRTMEPYRIFFPGSHPVRGVQVMKVGKLQLHQGMFPQAMKNLRLAFDIMRVTHGREHSLIEDLILLLEECDANIRAS
  
Inhibitor
Name:
BDBM321293
Synonyms:
5-cyclopropyl-N-((2R)-2-methyl-1- (vinylsulfonyl)piperidin-4-yl) isoxazole-3-carboxamide | US10179773, Compound 7 | US10669243, Compound 7
Type:
Small organic molecule
Emp. Form.:
C15H21N3O4S
Mol. Mass.:
339.41
SMILES:
C[C@@H]1CC(CCN1S(=O)(=O)C=C)NC(=O)c1cc(on1)C1CC1 |r|
Structure:
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