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Target
Sphingosine 1-phosphate receptor 5
Ligand
BDBM453375
Substrate
n/a
Meas. Tech.
Measurement of the Inhibitory Action of the Compound of the Present Invention on Binding of [33P]-S1P to S1P5 (EDG-8)
IC50
2000±n/a nM
Citation
 Watanabe, T; Kusumi, K; Inagaki, Y Tetrahydronaphthalene derivative US Patent  US10730830 Publication Date 8/4/2020 
Target
Name:
Sphingosine 1-phosphate receptor 5
Synonyms:
EDG8 | Endothelial differentiation sphingolipid G-protein-coupled receptor 8 | S1P5 | S1PR5 | S1PR5_HUMAN | Sphingosine 1-phosphate receptor | Sphingosine 1-phosphate receptor Edg-8
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
41796.42
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
398
Sequence:
MESGLLRPAPVSEVIVLHYNYTGKLRGARYQPGAGLRADAVVCLAVCAFIVLENLAVLLVLGRHPRFHAPMFLLLGSLTLSDLLAGAAYAANILLSGPLTLKLSPALWFAREGGVFVALTASVLSLLAIALERSLTMARRGPAPVSSRGRTLAMAAAAWGVSLLLGLLPALGWNCLGRLDACSTVLPLYAKAYVLFCVLAFVGILAAICALYARIYCQVRANARRLPARPGTAGTTSTRARRKPRSLALLRTLSVVLLAFVACWGPLFLLLLLDVACPARTCPVLLQADPFLGLAMANSLLNPIIYTLTNRDLRHALLRLVCCGRHSCGRDPSGSQQSASAAEASGGLRRCLPPGLDGSFSGSERSSPQRDGLDTSGSTGSPGAPTAARTLVSEPAAD
  
Inhibitor
Name:
BDBM453375
Synonyms:
4-[8-({(2E)-3-[4-(Trifluoromethyl)phenyl]-2-propen-1-yl}oxy)-3,4-dihydro-2(1H)-isoquinolinyl]butanoic Acid | US10730830, Example 18 (2)
Type:
Small organic molecule
Emp. Form.:
C23H24F3NO3
Mol. Mass.:
419.4368
SMILES:
OC(=O)CCCc1cccc2CCN(Cc12)OC\C=C\c1ccc(cc1)C(F)(F)F
Structure:
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